Gelatin ribbon

Fig. 2. Rotary die process of soft gelatin capsules where A represents the drug mix B, the mold wedge C, gelatin ribbons D, die roUs E, capsules and F,...

Speed of die rotation and gelatin ribbon thickness are two important machine conditions that are included in Table 5. The rationale of their selection is... 

Blend time to solubilize active ingredients Gelatin mass mix time and temperature Die rotation speed Gelatin ribbon thickness Relative humidity of encapsulation room Bulk assay Dissolution Average fill weight Dosage form assay Microbial content... 

A bloom strength determination is part of the acceptance criteria for each receipt of gelatin raw material. The bloom gelometer numbers range from 125 to 195 for the 12 lots, with a mean of 147. This number was compared to gelatin ribbon thickness and die rotation speed during encapsulation to ascertain whether lot-to-lot differences had to be compensated for. No relationship was found. 

The influence of gelatin mass temperature, gelatin ribbon thickness, and die speed on softgel formation and the interactions of these variables were explored by regression analysis as follows ... 

Finished softgel weight = gelatin mass temperature + die speed + gelatin ribbon thickness... 

Dugand, J.P.M. Multicolor Gelatin Ribbons and Manufacture of Soft Gelatin Products. US Patent 6,797,201, Sep 28, 2004. 

Soft elastic gelatin capsules arc prepared in a rotary die process from two continuous gelatin ribbons. The capsules are formed, filled, and sealed in accurately timed opera tions, and can be filled with any liquid, semiliquid, paste, or even powder that will not dissolve or interact with the gelatin. 

Amyl alcohol was used in France, beginning in 1896—7, as a stabilizer for the military propellant called Poudre B and were known as Poudres B(AM). The propellants were prepd from a mixt of sol and insol NC gelatinized with ether-alcohol to which some amyl alcohol was added. After incorporation, the mass was worked between rollers at 70° and the rolled sheets either cut into strips or extruded through a die into ribbons. It was then dried at 50° and washed with water. Amyl ale being less volatile than ether-ale remained in the finished product. Poudre B (AM2)t used for small caliber guns, contained 2% of amyl alcohol, whereas Poudte B(AM2) used for large naval guns contained... 

WAnmaTOtf and Redwoo4 have shown that sheet gelatin is rolled between sheets of isinglass in the moistened state, so as to form a ribbon in which the two substances would be united. 

The instructions for gelatin mass preparation direct that gelatin powder be blended with water, a plasticizer, and colorant until a uniform consistency is achieved, then heated until molten. The recommended blend time is 20 min at a temperature of 60°C + 5°. The temperature of the molten gelatin just prior to formation into a ribbon is critical too high a temperature causes the gelatin to deteriorate, and a low temperature affects flow rate. Both conditions are to be avoided for their deleterious effect on capsule formation. For these reasons,... 

The water present in the gel framework can be completely removed with some gelling agents. Gelatin sheets, acacia tears, and tragacanth ribbons are generally prepared by removal of water from their respective gel matrix. These dehydrated gel frameworks are called as xerogels. 

USP 2780997 (1957) 8t CA 51, 7014 (1957) (Manuf of colloidal proplnts by creating NC with acetone, followed by incorporating NG, nitrate salts, etc. The resulting gelatinous mass is extruded at high sheer from a die in the form of a sheet, ribbon, filament, etc and then the material is dried while being maintained under tension along the line of extrusion) J)A.Kraus,... 

Make 7-8 pm sections of the tissue with a conventional microtome. Arrange sectioned ribbons onto gelatin/chrome alum precoated slides and dry on a drymg bench at 45-50°C for a few minutes until the section ribbon stretches well after the compression caused by the sectioning. 

MC produced by the vinegar fermentation bacterium A. xylinum is synthesized in the form of twisting ribbons, which in stationary culture forms a thick, gelatinous membrane on the surface of a liquid medium. The membrane formed in such conditions is characterized by the 3D structure made of an ultrafine network of... 

In 1886, Brown reported that the gelatinous membrane is composed of a substance that is chemically identical to cellulose (1886). Electron microscopic observations in the 1940s revealed that bacterial cellulose consists of twisting ribbon-shaped fibrils (Muhlethaler 1949). The ribbons are approximately 20-50 nm in width, which is less than 1/lOOOth the width of plant pulp cellulose (Fig. 14.6). Each ribbon is composed of a number of microfibrils that may be observed under transmission electron microscopy (Brown et al. 1976 Zarr 1979). Acid hydrolyzation experiments have revealed that these microfibrils are composed of regularly repeating units (Hori et al. 1997). Microfibril size correlates with its crystallite size, as measured by X-ray diffraction (Nieduszy and Preston 1970). 

---