Gastrointestinal disease infectious

H. C. Neu, in J. C. Petrie, ed.. Gastrointestinal, Haematological and Infectious Disease Therapy, Elsevier Science PubHshers, Amsterdam, The Netherlands, 1985, p. 215. 

Inflammatory conditions of the GI tract may be initiated by a disregu-lated local immune response to the normal microbiota and are host dependent (Sartor, 2003 Shanahan, 2001). However, a subset of IBS patients experience symptoms following gastrointestinal infection (post-infectious IBS). In addition, underlying infection has been proposed as a possible trigger in Crohn s disease and both M. avium subsp. paratubercu-losis or adherent invasive E. coli (AIEC) have been suggested as possible sources of inflammation (Darfefeuille-Michaud et ah, 2004 Sechi et ah,... 

Inflammatory bowel disease (ulcerative colitis and Crohn s disease) is a general term for a group of chronic inflammatory disorders of unknown cause involving the gastrointestinal tract. Despite many attempts to confirm an infectious agent as the cause of disease, no bacterial. 

In a multicenter study from the National Institute of Allergy and Infectious Diseases in the USA, azithromycin (600 mg/day) plus rifabutin (300 mg/day) was poorly tolerated by 31 patients with or without HIV infection (14). Gastrointestinal symptoms and neutropenia were the major adverse effects. There was no significant pharmacokinetic interaction between the two drugs. 

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