Therapy of Infectious Diseases

Therapy of Infectious Diseases. In connection with side-chains of jS-lactams, several patents on the synthesis and purification of 2-thienylaceticacid,  

Tamura, N. Inukai, H. Iwamoto, I. Yanagisawa, Y. Ishii, T. Takagi, K. Tomioka, and M. Murakami, Yamanouchi Seiyaku Kenkyu Hokoku, 1980, 4, 16. 

Dolfini, USSR P. 812 184, 1981 (Otkrytiya, Izobret., Prom. Obraztsy, Tovarnye Znaki, 1981, 227). 

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Table 1. Tetracyclines Used for the Therapy of Infectious Diseases...

A large and rapidly growing number of clinical trials (phase I and phase II) evaluating the potential of DNA vaccines to treat and prevent a variety of human diseases are currently being performed ( http // clinicaltrials.gov) however, there is yet no licensed DNA vaccine product available for use in humans. The clinical trials include the treatment of various types of cancers (e.g., melanoma, breast, renal, lymphoma, prostate, and pancreas) and also the prevention and therapy of infectious diseases (e.g., HIV/ABDS, malaria, Hepatitis B vims, Influenza vims, and Dengue vims). So far, no principally adverse effects have been reported from these trials. The main challenge for the development of DNA vaccines for use in humans is to improve the rather weak potency. DNA vaccines are already commercially available for veterinary medicine for prevention of West Nile Vims infections in horses and Infectious Hematopoetic Necrosis Vims in Salmon. 

Allen, T. M. (1989). Stealth liposomes Avoiding reticuloendothelial uptake, in Liposomes in the Therapy of Infectious Diseases and Cancer (G. Lopez-Berestein and I. J. Fidler, eds.), Alan R. 

Millions of people died of infection before the discovery of antibiotics. During the early twentieth century and before, infectious diseases were cured by using potions and plant extracts. Patients were quarantined to keep the infections from spreading. At first, several scientists started their research by keeping records of the infectious diseases. As a result of this work, pioneers like Joseph Lister, Louis Pasteur, and Robert Koch have proven the existence of microbes and the way they are responsible for infections. Their use of disinfectants, antitoxins, vaccination and anti-infectives laid the foundation for modern day therapy of infectious diseases. 

Rondon, I.J., and W.A. Marasco. 1997. Intracellular antibodies (intrabodies) for gene therapy of infectious diseases. 

Paul Ehrlich made notable contributions in several areas of medicine including selective dye staining of cells, immunology, cancer research, and chemical therapy of infectious diseases. 

It is very important to select promptly the most effective antibiotic for successful therapy of infectious diseases, and wound and post-surgical infections. The duration of standard microbiology assays applied in clinical practice exceeds 3-5 days since preliminary isolation of the pathogen from the clinical sample is required. In the present study we optimized a rapid bio luminescent antibiotic susceptibility assay based on comparison of bacterial ATP concentrations (bioluminescent signals) in a control (aliquot of the sample, free of the antibiotic) and probe (aliquot of the sample, supplied with antibiotic examined) after short-time incubation. For validation of the proposed assay, bacteria strains isolated from clinical samples were analyzed in parallel by the Bioluminescent Assay and Standard Microbiology Assay - Disk Method or Serial Dilutions Method. 

Aminoglycoside antibiotics play a central role in the therapy of infectious diseases. Streptoniycm, the first member of this class, was isolated from the culture filtrate of Streptomyces griseus by S. A. Waksman in 1944. Since then a great number of new amino ycosides have been discovered and their structures elucidated. For many years they were considered unfavorable for therapeutic use as antibacterials, because of their oto- and nephrotoxicity and their lack of enteral absorption. 

NAKAi T and PARK s c (2002) Bacteriophage therapy of infectious diseases in aquaculture, Res Microbiol, 153,13-18. 

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