Pyloric gland-type adenomas

Nagata S, Ajioka Y, Nishikura K, et al. Co-expression of gastric and biliary phenotype in pyloric-gland type adenoma of the gallbladder immunohistochemical analysis of mucin profile and CDIO. Onco/Rep. 2007 17 721-729. 

Molecular alterations of gallbladder adenomas are fairly different than those observed in the conventional dysplasia-carcinoma sequence. Mutations of the p53 gene are virtually nonexistent in gallbladder adenomas and only rarely detected in EHBD tumors. In contrast, p53 abnormalities are quite common in flat dysplasia and invasive carcinoma. Similarly, mutation of the KRAS oncogene is detected in only 25% of gallbladder adenomas. In contrast, mutations of the -catenin gene, which are uncommon in invasive biliary carcinomas, have been detected in 60% of adenomas, mostly the pyloric gland type, and less commonly the papillary or intestinal typesA ... 

Kato N, Akiyama S, Motoyama T. Pyloric gland-type tubular adenoma superimposed on intraductal papillary mucinous m-mor of the pancreas. Pyloric gland adenoma of the pancreas. Virchows Arch. 2002 440 205-208. 

Nakayama Y, Inoue H, Hamada Y, et ak Intraductal tubular adenoma of the pancreas, pyloric gland type a clinicopathologic and immunohistochemical study of 6 cases. Am J Surg Pathol. 2005 29 607-616. 

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