Gastric secretion serum proteins

Gastric secretion represents a very complex naixture of electrolytes, water, carbohydrates, proteins, peptides, and amino acids, which are partly in solution and partly in more or less stable suspension. The large molecular materials of gastric secretion include enzymes, mucosubstances, serum proteins, peptides and products of proteolytic degradation of gastric proteins and mucoproteins, and blood group substances. 

From the information just cited, it appears that serum proteins are normal constituents of gastric juice and can be demonstrated even in acid secretion if proteolysis is prevented by in situ neutralization of gastric juice. 

H35. Hollander, F., and Horowitz, M. L, Serum proteins in gastric mucus and other secretions. Implications in relation to the protein-losing enteropathies. Gastroenterology 43, 75-83 (1962). 

H45. Horowitz, M. I., and Hollander, F., Serum proteins in anacid gastric mucinous secretion. J. Biol. Chem. 236, 770-773 (1961). 

The double immunodiffusion method was first applied by Holman et al. (H16) and Gullberg and Olhagen (G34) to detect albumin and y-glob-ulin in gastric juice. By this method, serum proteins were found in gastric juice from normal individuals and patients with various disease. Stimulation of gastric secretion with histamine diminished the serum protein concentration in gastric juice, which Holman et al. (H16) believed to be due to either proteolysis or dilution. 

I. Pharmacology. Potassium is the primary intracellular cation, which is essential for maintenance of acid-base balance, intracellular tonicity, transmission of nerve impulses, contraction of cardiac, skeletal, and smooth muscle, and maintenance of normal renal function (and ability to alkalinize urine). Potassium also acts as an activator in many enzyme reactions and participates in many physiological processes such as carbohydrate metabolism, protein synthesis, and gastric secretion. Potassium is critical in regulating nerve conduction and muscle contraction, especially in the heart. A variety of toxins cause alterations in serum potassium levels (see Table 1-27, p 38). 

Bieberdorf FA, Walsh JH, Fordtran IS. Effect of optimum therapeutic dose of poldine on acid secretion, gastric acidity, gastric emptying, and serum gastrin concentration after a protein meal. Gastroenterology 1975 68(l) 50-7. 

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