Gas chromatography mass spectrometry detection

GAS CHROMATOGRAPHY/MASS SPECTROMETRY DETECTION OF XENOBIOTICS IN ENVIRONMENTAL... 

Frias, S., M.A. Rodriquez, J.E. Conde, and J.P. Perez-Trujillo (2003). Optimization of a solid-phase microextraction procedure for the determination of triazines in water with gas chromatography-mass spectrometry detection. J. Chromatogr. A, 1007 127-135. 

Earina, L., Boido, E., Carrau, E, Delacassa, E. (2007). Determination of volatile phenols in red wines by dispersive liquid-liquid microextraction and gas chromatography-mass spectrometry detection. J. Chromatogr. A, 1157, 46-50. 

A Method Using Gas Chromatography - Mass Spectrometry Detection of Mycotoxins from Trichothecene Groups A and B... 

An interesting approach was developed by D Amico et al. (2008), in which they nsed an electronic nose sensor with a good sensitivity towards volatile organic compounds emitted by skin lesions from melanoma patients, and the method seems to be effective for identification of malignant lesions. The gas sensor nsed gas chromatography mass spectrometry detection and shows satisfactory accuracy. This approach does not use a biosensor bnt combines chemometric tools with a sensor that can be a favourable approach to detect a pattern in POC biomedical devices. 

ROLE OF COMPUTERS IN GAS CHROMATOGRAPHY-MASS SPECTROMETRY DETECTION, IDENTIFICATION, AND QUANTIFICATION IN DRUG METABOLISM RESEARCH... 

Serodio, P. and Nogueira, J.M.F. (2004) Multi-residue screening of endocrine disrupting chemicals in water samples by stir bar sorptive extraction gas chromatography mass spectrometry detection. Anal Chim. Acta, 517, 21—32. 

The active drug and metabolites can be detected from the urine by thin-layer chromatography, gas-liquid chromatography, or gas chromatography-mass spectrometry. However, assays are available only at specialized centers. Treatment of acute intoxication with mescaline is virtually identical to the treatment outlined for LSD intoxication. DOM-induced vasospasm responds well to intra-arterial tolazohne or sodium nitroprusside. Major life-threatening complications of hallucinogenic amphetamine derivatives include hyperthermia, hypertension, convulsions, cardiovascular collapse, and self-inflicted trauma. 

S. Alugupalli, L. Larsson, M. Slosarek, and M. Jare.sova, Application of gas chromatography-mass spectrometry for rapid detection of Mycobaaerimn. xenopi in drinking water, Appl. Environ. Microbiol. 5 3538 (1992). 

M. Slosarke, S. Alugupalli, J. Kaustova, L. Larsson, Rapid detection of Mycobater-ium kanasii in water by gas chromatography mass spectrometry, J. Microbiol. Methods 27 217 (1996). 

When pushed to the limit by overriding human health concerns, residue chemists have achieved detection limits of Ippt (Ingkg ) or even into the low ppqr (1 pg kg ) range. An example at the 1 ppt level is provided by methods for 2,3,7,8-tetrachlorodibenzodioxin (TCDD) in milk and TCDD in adipose tissue. Eor relatively clean matrices such as water and air, preconcentration on solid-phase adsorbents followed by GC or gas chromatography/mass spectrometry (GC/MS) can provide detection limits of 1 ng m and less for air (examples in Majewski and Capel ) and 1 ngL and less for water (examples in Larson et A summary of units of weight and concentration used to express residue data is given in Table 1. 

Morgan, S. L. Fox, A. Gilbart, J. Profiling, structural characterization, and trace detection of chemical markers for microorganisms by gas chromatography-mass spectrometry. J. Microbiol. Meth. 1989,9,57-69. 

If additional information pertaining to the rubber composition were sought, FTIR analysis of the pyrolysis products would have been performed. Even more detailed analysis can be obtained by gas chromatography (GC) separation of the multiple pyrolysis products followed by mass spectrometric (MS) detection. The gas chromatography-mass spectrometry (GC-MS) method is well suited to deformulation and contaminant analysis. 

A. F. L. Godoi, L. van Vaeck, R. vanGrieken, Use of solid phase microextraction for the detection of acetic acid by ion trap gas chromatography mass spectrometry and application to indoor levels in museums, J. Chromatogr. A, 1067, 331 336 (2005). 

Conductometric transducers, as the oldest electrochemical devices, seem not to enjoy wide applications due to their poor selectivity. For example, Yagiuda et al. proposed a conductometric immunosensor for the determination of methamphetamine (MA) in urine [89], The decrease in the conductivity between a pair of platinum electrodes might result from the direct attachment of MA onto the anti-MA antibodies immobilized on the electrode surface. The system was claimed to be a useful detection technique of MA in comparison with a gas chromatography-mass spectrometry method. 

Shinohara et al. [299] have described a procedure based on gas chromatography for the determination of traces of two, three, and five-ring azarenes in seawater. The procedure is based on the concentration of the compounds on Amberlite XAD-2 resin, separation by solvent partition [300], and determination by gas chromatography-mass spectrometry with a selective ion monitor. Detection limits by the flame thermionic detector were 0.5-3.0 ng and those by gas chromatography-mass spectrometry were in the range 0.02-0.5 ng. The preferred solvent for elution from the resin was dichloromethane and the recoveries were mainly in the range 89-94%. 

A variety of analytical techniques are used to measure PCP, including gas chromatography-mass spectrometry (GC-MS), which has a detection limit of 7.6 pg/kg honey (Muino and Taiza.no 1991), liquid chromatography with fluorescence detection (de Ruiter et al. 1990), and liquid chromatography-electrochemistry (LC-ED) procedures (Butler and Pont 1992). At present, GC-MS is the most accurate, but LC-ED is used most frequently (Butler and Pont 1992). 

---