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GABA imaging

Following the release of dopamine, the primary mode of removal from the synapse is reuptake into the presynaptic neuron via the dopamine transporter (DAT). DAT is dependent upon the energy created by the Na+/K+ pump and is a member of the Na+/Cl -dependent plasma membrane transporter family, as are the norepinephrine and 7-aminobutyric acid (GABA) transporters. Imaging studies utilizing compounds with highly specific affinity for DAT... [Pg.180]

Figure 1.2 Serotonin is one of the brain s neurotransmitters. This image depicts serotonin transmission between neurons and the drug Ecstasy s effects on that transmission. Serotonin is normally removed from the synapse shortly after being released. Ecstasy blocks this mechanism, increasing the amount of serotonin in the synapse. This causes the postsynaptic neuron to be overstimulated by serotonin. Serotonin is one of many neurotransmitters that nerve cells can secrete. Other common neurotransmitters include dopamine, glutamate, gamma aminobutyric acid (GABA), noradrenaline, and endorphins. Figure 1.2 Serotonin is one of the brain s neurotransmitters. This image depicts serotonin transmission between neurons and the drug Ecstasy s effects on that transmission. Serotonin is normally removed from the synapse shortly after being released. Ecstasy blocks this mechanism, increasing the amount of serotonin in the synapse. This causes the postsynaptic neuron to be overstimulated by serotonin. Serotonin is one of many neurotransmitters that nerve cells can secrete. Other common neurotransmitters include dopamine, glutamate, gamma aminobutyric acid (GABA), noradrenaline, and endorphins.
Owens DF, Boyce LH, Davis MB, Kriegstein AR (1996) Excitatory GABA responses in embryonic and neonatal cortical slices demonstrated by gramicidin perforated-patch recordings and calcium imaging. J Neurosci 16 6414-23... [Pg.523]

NCA 125I and 123I in 50-70% radiochemical yield. 265 is specific for the benzodiazepine-GABA receptor in human brain imaging studies409. [Pg.482]

Radiolabelled benzodiazepine antagonists 346 useful for the in vivo imaging and quantitation of benzodiazepine-GABA receptor sites in the human brain327,328 have been synthesized in 50-70% radiochemical yield and >98% purity by a one-step Pd-catalysed reaction329 between bis(tributyltin) and Ro 16-0154, 347, followed by electrophilic iodination of the tributyl tin compound 348 with no-carrier-added 125I and 123I (equation 148). [Pg.1226]

Petroff OA, Pleban LA, Spencer DD (1995) Symbiosis between in vivo and in vitro NMR spectroscopy The creatine, N-acety-laspartate, glutamate, and GABA content of the epileptic human brain. Magn Reson Imaging 13 1197-1211. [Pg.763]

Understanding Alterations During Human Brain Development with Molecular Imaging Role in Determining Serotonin and GABA Mechanisms in Autism... [Pg.83]

Fig. 111. Typical distribution of glutamate-like and GABA-like immunoreactive neurons in the nucleus lateralis of rat cerebellum. Consecutive sections immunostained for glutamate (A) and GABA (B) are shown as mirror images. Note the difference in size of the stained neurons. Batini et al. (1992). Fig. 111. Typical distribution of glutamate-like and GABA-like immunoreactive neurons in the nucleus lateralis of rat cerebellum. Consecutive sections immunostained for glutamate (A) and GABA (B) are shown as mirror images. Note the difference in size of the stained neurons. Batini et al. (1992).
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See also in sourсe #XX -- [ Pg.34 ]



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