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Radiolabeled benzodiazepine

Radiolabelled benzodiazepine antagonists 346 useful for the in vivo imaging and quantitation of benzodiazepine-GABA receptor sites in the human brain327,328 have been synthesized in 50-70% radiochemical yield and >98% purity by a one-step Pd-catalysed reaction329 between bis(tributyltin) and Ro 16-0154, 347, followed by electrophilic iodination of the tributyl tin compound 348 with no-carrier-added 125I and 123I (equation 148). [Pg.1226]

The affinity and selectivity of 1,5-benzodiazepines with different substitution pattern was studied in either guinea-pig cortical membranes (CCK-B receptors) or in rat pancreatic membranes (CCK-A receptors) using radiolabelled binding studies. [Pg.381]

See other pages where Radiolabeled benzodiazepine is mentioned: [Pg.272]    [Pg.195]    [Pg.916]    [Pg.272]    [Pg.195]    [Pg.916]    [Pg.235]    [Pg.240]    [Pg.3116]    [Pg.24]    [Pg.124]    [Pg.120]    [Pg.335]    [Pg.569]   
See also in sourсe #XX -- [ Pg.195 ]



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