Shared receptors

There are known to be three opioid receptors, designated p, k, and 8, and these receptors share a high degree of amino acid sequence homology. The p-opioid receptor (MOR) is the primary receptor, which is activated by the nonselective... 

STD has also been shown to be regulated by farnesoid X receptor (FXR) [34], CAR [35] and liver X receptor (LXR) [36]. Interestingly, all four receptors share the same IR-0 response element to regulate the expression of this S ULT isoform. The hierarchy and relative contribution of individual nuclear receptors in Sult2a regulation remain to be determined. 

B., Goodwin, B., Liddle, C. Blanchard, S. G., Willson, T.M., Collins, J.L. and Kliewer, S.A (2000) Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. The Journal of Biological Chemistry, 275, 15122-15127. 

These receptors share several common features, some of which are illustrated in our example, the cysteinyl leukotriene 2 (CysLT ) receptor (see Fig. 6.1) (11). These features include (1) insertion into the membrane and targeting to the plasma membrane of the cell (2) the presence of seven conserved transmembrane domains (3) three extracellular and three intracellular loops (4) an extracellular amino terminus and (5) an intracellular carboxyl terminus (1,2). 

A second superfamily of receptors shares a common molecular makeup in which every member has four transmembrane regions, with five copies of each receptor configured around an ion channel (represented as icons in Figs. 3—3 and 3—4 see... 

Hamdan et al. (2002) describe another biogenic amine-responsive GPCR in the tegument of S. mansoni, which specifically binds to and is activated by histamine. This cloned receptor shares approximately 30% amino acid sequence homology with other major amine GPCRs, and, when transfected into mammalian cells exhibited the following characteristics ... 

Figure 17.3 The nuclear receptor superfamily. Steroid receptor family members and thyroid receptor family members differ in several structural and functional properties. The estrogen receptors share properties with both steroid and thyroid receptor families and are likely an evolutionary precursor to both families.

A subset of FRAPs and 5-HT receptors share ultrastructural similarities, suggesting their close proximities in specialized subcellular regions. Confocal and electron microscopy demonstrated a concentration of 5-HT2C receptors in the microvilli bordering the apical surface of the epithelial cells in the choroids plexus where they colocalize with Veli-3 and MUPP1, both of which have been... 

These receptors share quite similar DNA-binding domains and differ somewhat more in their hormone-binding regions as shown in Figure 7-5. Additionally, they have very different activation domains, which interact with other parts of the transcription machinery. 

Immunosuppression or enhancement can be associated with two distinct groups (1) Drugs intended to modulate immune function for therapeutic purposes (e.g. to prevent organ transplant rejection) where adverse immunosuppression can be considered exaggerated pharmacodynamics. (2) Drugs not intended to affect immune function but cause immunotoxicity due, for instance, to necrosis or apoptosis of immune cells or interaction with cellular receptors shared by... 

After the introduction of gene cloning methodologies, three new receptor subtypes, D3, D4 and D5, were characterized over the years. Characterization of complementary DNA for all five receptor subtypes showed that D3 and D5 receptors share high homology in their transmembrane sequences similarly, the transmembrane sequences of D2, D3 and D4 receptors are conserved in the three receptor species (Missale et al., 1998). 

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