Furosemide interaction

Uses Edema, HTN, CHF, h atic cirrhosis Action Loop diuretic -1- reabsorption of Na Cr in ascending loop of Henle distal tubule Dose 5-20 mg/d PO or IV 200 mg/d max Caution [B, ] Contra Sulfonylurea sensitivity Disp Tabs, inj SE Orthostatic -1- BP, HA, dizziness, photosens, electrolyte imbalance, blurred vision, renal impair Notes 20 mg torsemide = 40 mg furosemide Interactions t Risk of ototox W/ aminoglycosides, cisplatin t effects W/ thiazides t effects OF anticoagulants, antih5rpCTtensives, Li, salicylates X effects IT/barbiturates, carbamaz ine, cholestyramine, NSAIDs, phenytoin, phenobarbital, probenecid, dandehon EMS t Effects of anticoagulants monitor for S/Sxs tinnitus, monitor ECG for hypokalemia (flattened T waves) OD May cause HA, hypotension, hypovolemia, and hypokalemia give IV fluids symptomatic and supportive... 

Thomsen J, Bech P, Szpirt W. Otologic symptoms in chronic renal failure. The possible role of aminoglycoside-furosemide interaction. Arch Otorhinolaryngol 1976 214(l) 71-9. 

Lawson DH, Tilstc WJ, Semple PF. Furosemide interactions studies in normal volunteers. CfiwR 5(1976)24,3. 

Much less is known about the interactions of NSAIDs with bumetanide, and even less about piretanide and torasemide, but the evidence suggests that they probably interact in the same way as furosemide and indomet-acin. It would therefore seem prudent to be alert for interactions with any of the NSAIDs with which furosemide interacts. See also Loop diuretics + Aspirin , p.948, for a discussion of the interactions between aspirin and bumetanide or furosemide. 

Tobert JA, Ostaszewski T, Reger B, Mesinger MAP, Cook TJ. Diflunisal-furosemide interaction. Clin Pharmacol Ther ( 9S0) 27, 289-90. 

Rosenkranz B, Lehr K-H, Mackert G, Seyberth HW. Metarnizole-furosemide interaction study in healthy volunteers. EurJ Clin Pharmacol (1992) 42, 593-8. 

Ab initio method was used for synthesis of MlPs for furosemide, which is a potent diuretic drug [Bagher et al., 2010]. The AE values were calculated through HF/6-31G[d]. The furosemide interacted more strongly with acrylamide [AAm] in comparison with other functional monomers. Using AAM-based MlPs, a MISPE procedure was developed for the cleanup of furosemide with sufficient accuracy and precision for trace analysis in plasma samples. 

Drug/Food interactions The bioavailability of furosemide is decreased and its... 

This study also suggests that molecular size and structure play a role in this interaction. The binding behaviors of dextrin oligomers for four different pharmaceuticals (ibuprofen, ketoprofen, furosemide, and warfarin) were observed under the same experimental conditions. Ibuprofen and ketoprofen, two compounds that are similar in chemical structure and pharmaceutical use, showed obvious differences in interaction patterns (Fig. 13A and B). Ketoprofen, having an extra aromatic ring, required an octa-saccharide (DP = 8) for binding, whereas ibuprofen required a heptasac-... 

Uses Severe, systemic fungal Infxns oral cutaneous candidiasis Action Binds ergosterol in the fungal membrane to alter permeability Dose Adults Peds. Test dose 1 mg IV adults or 0.1 mg/kg to 1 mg IV in children then 0.25-1.5 mg/kg/24 h IV over 2-6 h (range 25-50 mg/d or qod). Total dose varies w/ indication PO 1 mL qid Caution [B, ] Disp Inj SE -1- K /Mg from renal wasting anaphylaxis reported, HA, fever, chills, n hrotox, -1- BP, anemia, rigors Notes -1- In renal impair pre-Tx w/ APAP antihistamines (Benadryl) X SE Interactions T Nephrotoxic effects W/ antineoplastics, cyclosporine, furosemide, vancomycin, aminoglycosides, T hypokalemia W/ corticost oids, skeletal muscle relaxants EMS May cause electrolyte imbalances, monitor ECG OD May effect CV and resp Fxn symptomatic and supportive... 

Uses Infxns of resp tract, skin/soft tissue, scarlet fevCT, S5 philis Action Bactericidal -1- cell wall synth Dose Adults. 0.6-4.8 million Units/d in doses ql2-24h give probenecid at least 30 min prior to PCN to prolong action Feds. 25,000-50,000 Units/kg/d IM daily-bid Caution [B, M] Contra AU gy Disp Inj SE Pain at inj site, int stitial n hritis, anaphylaxis Interactions t Effects W/probenecid t penicillin 1/2-life Wf ASA, furosemide, indomethacin, sulfonamides, thiazide diuretics T risk of bleeding W/ anticoagulants -1- effects Wf chloramphenicol, macrolides, tetracyclines -1- effects OF OCPs EMS See Penicillin G, Aqueous OD See Penicillin G, Aqueous... 

Bindschedler M., P. Degen, G. Flesch, M. de Gasparo, and G. Preiswerk (1997). Pharmacokinetics and pharmacodynamic interaction of single oral doses of valsartan and furosemide. European Journal of Clinical Pharmacology 52 371-378. 

Almost all diuretics exert their action at the luminal surface of the renal tubule cells. Their mechanism of action includes interaction with specific membrane transport proteins like thiazides, furosemide etc., osmotic effects which prevent the water permeable segments of the nephron from absorbing water like mannitol, and specific interaction with enzyme like carbonic anhydrase inhibitors i.e. acetazolamide, and hormone receptors in renal epithelial cells like spironolactone. 

---