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Funnel-web spider

DHPs, dihydropyridines (eg, nifedipine) sFTX, synthetic funnel web spider toxin m-CTX, conotoxins extracted from several marine snails of the genus Conus -aga-IIIA and co-aga-IVA, toxins of the funnel web spider, Agelenopsis aperta SNX-482, a toxin of the African tarantula, Hysterocrates gigas. [Pg.259]

Agatoxin (oo-AGA-IVA) Blocks P-type channel Funnel web spider... [Pg.450]

P-type channels inactivate extremely slowly and are insensitive to both DHPs and co-conotoxin GVIA, but are blocked by the spider venom peptide co-agatoxin IVA, a peptide consisting of 48 amino acids isolated from the American funnel-web spider Agelenopsis aperta. [Pg.362]

Atracotoxins] (polypeptides) Funnel web spiders (Australia) V-JNa+ CH activators (persistent open state, inactivation inhibited)... [Pg.141]

We have previously isolated a 48-amino-acid peptide, named (u-agatoxin-TK (co-Aga-TK), from the venom of the funnel web spider, Agelenopsis aperta. It was found to be a potent blocker of the P-type calcium channels in rat cerebellar Purkinje neurons, but... [Pg.543]

Watanabe, T., Shikata, Y., Oda, Y., Nishizawa, Y., Kuwada, M., and Asakawa N. The two dimensional HPLC purification of biologically active polypeptides and polyamines in funnel web spider venom, manuscript in preparation... [Pg.554]

Figure 14 Comparison of 2D NOESY and 3D 15N-edited NOESY-HSQC spectra of a 41-residue peptide toxin from the Australian funnel-web spider Hadronyche infensa. A strip from the 2D NOESY spectrum is shown on the far left and it illustrates overlapping NOE correlations from three different amide protons (those of Trp13, Lys17, and Gly33). Fortunately, the 15N nuclei for these three amide groups have unique chemical shifts and hence they appear on different 2D planes in the 3D NOESY-HSQC experiment. Strips from these three planes are shown on the right, and they demonstrate that all of the NOE correlations are perfectly resolved in the 3D experiment. Figure 14 Comparison of 2D NOESY and 3D 15N-edited NOESY-HSQC spectra of a 41-residue peptide toxin from the Australian funnel-web spider Hadronyche infensa. A strip from the 2D NOESY spectrum is shown on the far left and it illustrates overlapping NOE correlations from three different amide protons (those of Trp13, Lys17, and Gly33). Fortunately, the 15N nuclei for these three amide groups have unique chemical shifts and hence they appear on different 2D planes in the 3D NOESY-HSQC experiment. Strips from these three planes are shown on the right, and they demonstrate that all of the NOE correlations are perfectly resolved in the 3D experiment.
Funnel-Web Spider, Tree-Dwelling Common Names Southern Tree Funnel-Web Spider Dwelling Funnel-Web... [Pg.22]

Also known as atraxin. Toxic component of the funnel web spider Atrax robustus. Disrupts ACh vesicles and depletes the nerve terminals of ACh. MW 15 000-20 000. Activates Na channels. [Pg.667]

Figure 41 Typical acylpolyamines identified in spider venom, including Agel464 (158) from the funnel web spider Agelenopsis aperta, NPTX10 (1) and joramine (160) from Nephila clavata and pseudoargiopinine 1 (159) from/Argi/ope lobata. 161 and 162 were identified recently from Coelotes pastoralis venom. Figure 41 Typical acylpolyamines identified in spider venom, including Agel464 (158) from the funnel web spider Agelenopsis aperta, NPTX10 (1) and joramine (160) from Nephila clavata and pseudoargiopinine 1 (159) from/Argi/ope lobata. 161 and 162 were identified recently from Coelotes pastoralis venom.
My threat is being bitten by a poisonous insect or even spider. I will assume that a single bite is debilitating, or even deadly, and should be avoided wherever possible. This could be either the bite from the lethal Sydney funnel-web spider or from a brown recluse spider or a sting from a common bumblebee when the individual is allergic to it. Unlike some of the chemical risks discussed earlier, where the actual threat to humans is debatable, there is no doubt that venomous pests present a serious health hazard to certain individuals. [Pg.85]

The P-type channels were first observed in the Purkinje cells and are inhibited by a toxin derived from a funnel-web spider poison, but not by other calcium channel-blocking agents. P-type channels are widely distributed throughout the CNS... [Pg.120]

Many other polyamines are known. Among these are a 4-aminobutylcadaverine isolated from root nodules of the adzuki bean and very long partially aromatic hydroxylamine derivatives from venom of common funnel-web spiders (structures at top of page). Cationic polypeptides called silaffins, with masses of 3 kDa, apparently initiate the growth of the silica cell walls of diatoms (Box 4-B). These peptides contain polyamines consisting of 6 to 11 repeated N-methylpropylamine imits covalently attached to lysine residues and also many phosphoserines. ... [Pg.447]

P-type Ca channels were first described by Llinas et al. [29] in cerebellar Purkinje cells, in which Ca currents were resistant to blockade by DHPs and co-conotoxin GVIA. The toxin fraction from the venom of the funnel web spider A. aperta (FTX) was found effectively to block this resistant current, and these results led these authors to suggest the existence of a new subtype of HVA Ca " channel, which was termed P (for Purkinje ). [Pg.115]

Adams ME, Bindokas VP, Hasegawa L, Venema VJ. Omega-agatoxins novel calcium channel antagonists of two snbtypes from funnel web spider (Agelenopsis aperta) venom. J Biol Chem 1990 265 (2) 861-7. [Pg.137]

Adams ME, Herold EE, Venema VJ. Two classes of channel-specific toxins from funnel web spider venom. J Comp Physiol [A] 1989 164(3) 333 2. [Pg.138]

Llinas R, Sugimori M, Lin JW, Cherksey B. Blocking and isolation of a calcium channel from neurons in mammals and cephalopods utilizing a toxin fraction (FTX) from funnel-web spider poison. Proc Natl Acad Sci U S A 1989 86(5) 1689-93. [Pg.138]

Duarte CB, Rosario LM, Sena CM, Carvalho AR A toxin fraction (FTX) from the funnel-web spider poison inhibits dihydropyridine-insensitive Ca channels coupled to catecholamine release in bovine adrenal chromaffin cells. J Neurochem 1993 60(3) 908-13. [Pg.145]

See other pages where Funnel-web spider is mentioned: [Pg.1173]    [Pg.73]    [Pg.45]    [Pg.48]    [Pg.409]    [Pg.425]    [Pg.264]    [Pg.1381]    [Pg.54]    [Pg.142]    [Pg.1173]    [Pg.61]    [Pg.22]    [Pg.22]    [Pg.81]    [Pg.86]    [Pg.345]    [Pg.352]    [Pg.353]    [Pg.354]    [Pg.355]    [Pg.356]    [Pg.361]    [Pg.468]    [Pg.121]    [Pg.227]    [Pg.256]    [Pg.600]   
See also in sourсe #XX -- [ Pg.409 ]



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FUNNELLING

Funnels

Spidering

Spiders webs

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