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Agelenopsis aperta

DHPs, dihydropyridines (eg, nifedipine) sFTX, synthetic funnel web spider toxin m-CTX, conotoxins extracted from several marine snails of the genus Conus -aga-IIIA and co-aga-IVA, toxins of the funnel web spider, Agelenopsis aperta SNX-482, a toxin of the African tarantula, Hysterocrates gigas. [Pg.259]

P-type channels inactivate extremely slowly and are insensitive to both DHPs and co-conotoxin GVIA, but are blocked by the spider venom peptide co-agatoxin IVA, a peptide consisting of 48 amino acids isolated from the American funnel-web spider Agelenopsis aperta. [Pg.362]

We have previously isolated a 48-amino-acid peptide, named (u-agatoxin-TK (co-Aga-TK), from the venom of the funnel web spider, Agelenopsis aperta. It was found to be a potent blocker of the P-type calcium channels in rat cerebellar Purkinje neurons, but... [Pg.543]

Figure 41 Typical acylpolyamines identified in spider venom, including Agel464 (158) from the funnel web spider Agelenopsis aperta, NPTX10 (1) and joramine (160) from Nephila clavata and pseudoargiopinine 1 (159) from/Argi/ope lobata. 161 and 162 were identified recently from Coelotes pastoralis venom. Figure 41 Typical acylpolyamines identified in spider venom, including Agel464 (158) from the funnel web spider Agelenopsis aperta, NPTX10 (1) and joramine (160) from Nephila clavata and pseudoargiopinine 1 (159) from/Argi/ope lobata. 161 and 162 were identified recently from Coelotes pastoralis venom.
Adams ME, Bindokas VP, Hasegawa L, Venema VJ. Omega-agatoxins novel calcium channel antagonists of two snbtypes from funnel web spider (Agelenopsis aperta) venom. J Biol Chem 1990 265 (2) 861-7. [Pg.137]

We initially sought to explain the biochemical basis of venom-induced insect paralysis by spider venom components. Using an electrophysiological assay for synaptic transmission, we deflned three classes of ion channel specific toxins, the a-, p- and co-agatoxins from Agelenopsis aperta venom. Two different types of co-agatoxins (Types I and II) were found to block insect presynaptic calcium channels. [Pg.251]

Jackson H, Usherwood PN (1988) Spider toxins as tools for dissecting elements of excitatory amino add transmission. Trends Neurosci 11 278-283 Jasys VJ, Kelbaugh PR, Nason DM, PhiUips D, Rosnack KJ, Saccomano NA, Stroh JG, VoUonann RA (1990) Isolation, structure elucidation, and synthesis of novel hydroxylamine-containing polyamines from the venom of the Agelenopsis aperta spider. J Am Chem Soc 112 6696-6704... [Pg.211]

Pttfks TN, Mueller AL, Artman LD, Albensi BC, Nemeth EF, Jackson H, Jasys VJ, Saccomano NA, Volkmann RA (1991) Arylamine toxins from funnel-web pider (Agelenopsis aperta) venom antagonize Af-methyl-o-aspartate receptor function in mammalian brain. J Biol Chem 266 21523-21529... [Pg.213]

See other pages where Agelenopsis aperta is mentioned: [Pg.425]    [Pg.54]    [Pg.350]    [Pg.353]    [Pg.544]    [Pg.547]    [Pg.389]    [Pg.346]    [Pg.352]    [Pg.354]    [Pg.73]    [Pg.108]    [Pg.250]    [Pg.254]    [Pg.255]    [Pg.256]    [Pg.52]    [Pg.203]    [Pg.211]    [Pg.213]    [Pg.213]   
See also in sourсe #XX -- [ Pg.350 , Pg.353 ]

See also in sourсe #XX -- [ Pg.19 , Pg.675 ]

See also in sourсe #XX -- [ Pg.19 , Pg.675 ]

See also in sourсe #XX -- [ Pg.152 ]



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