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Spiders venom

The occurrence of sulfated nucleoside glycosides in spider venoms, or for that matter in any other natural source, does not seem to have been previously noted. We look forward to the possibility that this novel... [Pg.45]

G. M. Nichoison, Spider Venom Peptides. In Handbook of Biologically Active Peptides] J. Kastin, Ed. Elsevier Amsterdam,... [Pg.300]

Widow spider venom Black widow Nervous system... [Pg.95]

We noted above that too much acetylcholine in the synapse or at a neuromuscular junction can be a problem black widow spider venom works that way by causing massive release of this neurotransmitter. There is another way to accomplish the same thing inhibit the normal route by which acetylcholine once released is subsequently removed. That route is degradation by acetylcholinesterase, an enzyme that catalyzes... [Pg.294]

Escoubas, P, Diochot, S. and Corzo, G. (2000). Structure and pharmacology of spider venom neurotoxins. Biochimie 82 893-907. [Pg.145]

Grishin, E. V. (1996). Neurotoxin from black widow spider venom. Structure and function. Advances in Experimental Medicine and Biology 391 231-236. [Pg.145]

McCormick, K.D. and Meinwald, J. (1993). Neurotoxic acylpolyamines from spider venoms. Journal of Chemical Ecology 19 2411-2451. [Pg.147]

P-type channels inactivate extremely slowly and are insensitive to both DHPs and co-conotoxin GVIA, but are blocked by the spider venom peptide co-agatoxin IVA, a peptide consisting of 48 amino acids isolated from the American funnel-web spider Agelenopsis aperta. [Pg.362]

Abstract a-Latrotoxin (a-LTX) from black widow spider venom induces exhaustive release of neurotransmitters from vertebrate nerve terminals and endocrine cells. This 130-kDa protein has been employed for many years as a molecular tool to study exocytosis. However, its action is complex in neurons, a-LTX induces massive secretion both in the presence of extracellular Ca2+ (Ca2+e) and in its absence in endocrine cells, it usually requires Ca2+e. To use this toxin for further dissection of secretory mechanisms, one needs an in-depth understanding of its... [Pg.171]

Ceccarelli B, Grohovaz F, Hurlbut WP (1979) Freeze-fracture studies of frog neuromuscular junctions during intense release of neurotransmitter. I. Effects of black widow spider venom and Ca2+-free solutions on the structure of the active zone. J Cell Biol 81 163-77 Ceccarelli B, Hurlbut WP (1980) Ca2+-dependent recycling of synaptic vesicles at the frog neuromuscular junction. J Cell Biol 87 297-303... [Pg.200]

Dudanova I, Sedej S, Ahmad M et al (2006) Important contribution of a-neurexins to Ca2+-triggered exocytosis of secretory granules. J Neurosci 26 10599-613 Fesce R, Segal JR, Ceccarelli B et al (1986) Effects of black widow spider venom and Ca2+ on quantal secretion at the frog neuromuscular junction. J Gen Physiol 88 59-81 Filippov AK, Tertishnikova SM, Alekseev AE et al (1994) Mechanism of a-latrotoxin action as revealed by patch-clamp experiments on Xenopus oocytes injected with rat brain messenger RNA. Neuroscience 61 179-89... [Pg.201]

Finkelstein A, Rubin LL, Tzeng M-C (1976) Black widow spider venom effect of purified toxin on lipid bilayer membranes. Science 193 1009-11 Fredriksson R, Schioth HB (2005) The repertoire of G-protein-coupled receptors in fully sequenced genomes. Mol Pharmacol 67 1414-25... [Pg.201]

Frontali N, Ceccarelli B, Gorio A et al (1976) Purification from black widow spider venom of a protein factor causing the depletion of synaptic vesicles at neuromuscular junctions. J Cell Biol... [Pg.201]

Hlubek MD, Stuenkel EL, Krasnoperov VG et al (2000) Calcium-independent receptor for a-latrotoxin and neurexin la facilitate toxin-induced channel formation evidence that channel formation results from tethering of toxin to membrane. Mol Pharmacol 57 519-28 Hurlbut WP, Ceccarelli B (1979) Use of black widow spider venom to study the release of neurotransmitters. Adv Cytopharmacol 3 87-115 87-115 Hurlbut WP, Chieregatti E, Valtorta F et al (1994) a-Latrotoxin channels in neuroblastoma cells. JMembr Biol 138 91-102... [Pg.201]


See other pages where Spiders venom is mentioned: [Pg.490]    [Pg.1173]    [Pg.635]    [Pg.373]    [Pg.44]    [Pg.44]    [Pg.48]    [Pg.221]    [Pg.233]    [Pg.287]    [Pg.292]    [Pg.292]    [Pg.293]    [Pg.504]    [Pg.405]    [Pg.342]    [Pg.343]    [Pg.262]    [Pg.125]    [Pg.75]    [Pg.406]    [Pg.292]    [Pg.201]    [Pg.214]    [Pg.372]    [Pg.125]    [Pg.70]    [Pg.118]    [Pg.166]    [Pg.172]    [Pg.201]    [Pg.202]   
See also in sourсe #XX -- [ Pg.34 , Pg.35 ]

See also in sourсe #XX -- [ Pg.139 ]




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