Fungicides chiral compounds

Chiral Effects Traditional methodology in synthetic organic chemistry led to racemic mixtures of chiral compounds. Recent developments, however, have made it possible to both synthesize the pure enantiomers and resolve them analytically. The fungicide, metalaxyl, contains a chiral carbon and the two enantiomers... 

Resolution of compounds made as diastereoisomeric mixtures The synthesis of Jacobsen s Mn(III) epoxidation catalyst by resolution Resolution with half an equivalent of resolving agent Physical Separation of Enantiomers Chromatography on chiral columns Resolution of triazole fungicides by HPLC A commercial drug separation by chiral HPLC Differential Crystallisation or Entrainment of Racemates Conglomerates and racemic compounds Typical procedure for differential crystallisation (entrainment) Conventional resolution ofL-methyl DOPA Resolution ofL-methyl DOPA by differential crystallisation Finding a differential crystallisation approach to fenfluramine Resolution with Racemisation... 

A large series of fungicidal N-aryl-4-pyridones has been described in patents (87EPP239391). Atropisomers were claimed without reported examples (lOUSPl 60385). At the time of this review, the chirality issues in these compounds, with possible interesting applications, have not yet been addressed. 

Chiral GC is successfiilly used for the precise determination of the enantiomeric composition of volatile natural compounds, authenticity control of essential oils, flavors, fragrances, some chiral research tiiemicals, auxiliaries, a few volatile drugs, drug metabolites, pesticides, fungicides, herbicides, pheromones, etc. [13]. 

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