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Multiple-copy simultaneous search methods

Miranker A, Karplus M. Functionality maps of binding sites a multiple copy simultaneous search method. Proteins 1991 11 29-34. [Pg.30]

Maps of Binding Sites A Multiple Copy Simultaneous Search Method. [Pg.54]

Miranker A and M Karplus 1991. Functionality Maps of Binding Sites - A Multiple Copy Simultaneous Search Method. Proteins Structure, Function and Genetics 11 29-34. [Pg.724]

To overcome the limitations of the database search methods, conformational search methods were developed [95,96,109]. There are many such methods, exploiting different protein representations, objective function tenns, and optimization or enumeration algorithms. The search algorithms include the minimum perturbation method [97], molecular dynamics simulations [92,110,111], genetic algorithms [112], Monte Carlo and simulated annealing [113,114], multiple copy simultaneous search [115-117], self-consistent field optimization [118], and an enumeration based on the graph theory [119]. [Pg.286]

A somewhat different approach has been implemented in MCSS (multiple copies simultaneous search) [10]. In this method, up to 5000 copies of a functional group are randomly distributed in the binding pocket and simultaneously minimized by a force field. The simultaneous optimization is performed in... [Pg.173]

Joseph-McCarthy, D., Hogle, J. M. and Karplus, M. (1997). Use of the multiple copy simultaneous search (MCSS) method to design a new class of picomavirus capsid binding drugs. Proteins, 29, 32-58. [Pg.897]


See other pages where Multiple-copy simultaneous search methods is mentioned: [Pg.483]    [Pg.298]    [Pg.208]    [Pg.276]    [Pg.483]    [Pg.298]    [Pg.208]    [Pg.276]    [Pg.704]    [Pg.324]    [Pg.148]    [Pg.688]    [Pg.252]    [Pg.72]    [Pg.413]    [Pg.378]   
See also in sourсe #XX -- [ Pg.298 ]

See also in sourсe #XX -- [ Pg.298 ]




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Methods multiple

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Multiple copy simultaneous search

Search methods

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Searching methods

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