Heterogeneities functions

Sloane AJ, Raso V, Dimitrov DS, et al. Marked structural and functional heterogeneity in CXCR4 separation of HIV-1 and SDF-lalpha responses. Immunol Cell Biol 2005 83(2) 129-143. 

Miklos, I. H. Kovacs, K. J. (2003). Functional heterogeneity of the responses of histaminergic neuron subpopulations to various stress challenges. Eur. J. 

O Garra, A. (1998) Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8, 275-283. 

Brady, S. T. A kinesin medley biochemical and functional heterogeneity. Trends Cell Biol. 5 159-164,1995. 

Wiegand SJ, Terasawa E (1982) Discrete lesions reveal functional heterogeneity of suprachiasmatic structures in regulation of gonadotropin secretion in the female rat. Neuroendocrinology 34 395-44... 

Geyer, M. A. (1975) Functional heterogeneity within neurotransmitter systems. Psychophar-macol. Commun., 1 675-686. 

Tabo, J.D. and Paul, W.E. (1973). Functional heterogeneity of murine lymphoid cells. III. Differential responsiveness of T cells to phytohemagglutinin and concanavalin A for T cell subsets. J. Immunol. 110 362-369. 

Sokurenko, E. V., Courtney, H. S., Ohman, D. E., Klemm, P., and Hasty, D. L. (1994). FimH family of type 1 fimbrial adhesins Functional heterogeneity due to minor sequence variations among finiH genes. J. Bacterial. 176, 748-755. 

Fishman, M. (1980). Functional heterogeneity among peritoneal macrophages. Cell. Im-munol. 55, 174-184. 

Trulson A, Bystrom J, Engstrom A, Larsson R, Venge P. 2007. The functional heterogeneity of eosinophil cationic protein is determined by a gene polymorphism and post-translational modifications. Clin Exp Allergy. 37 208-218. 

Harding, C.R., and I.R. Scott. 1983. Histidine-rich proteins (filaggrins) Structural and functional heterogeneity during epidermal differentiation. J Mol Biol 170 651. 

Thomas, N. L., George, C. H., and Lai, F. A. (2004). Functional Heterogeneity of Ryanodine Receptor Mutations Associated with Sudden Cardiac Death. Cardiovasc Res 64(1) 52-60. 

Gerritsen ME. Functional heterogeneity of vascular endothelial cells. Biochem Pharmacol 1987 36 2701-2711. 

Laskin DL, Weinberger B, Laskin JD. Functional heterogeneity in liver and lung macrophages. Journal of Leukocyte Biology 2001, 70, 163-170. 

More recently, Perrella et al. (1992) have carried out a kinetic investigation on the binding of CO to Hb A. They find that the functional heterogeneity of the a and (3 chains of Hb A is dependent on the nature of allosteric effectors. In 0.1 M KC1 at pH 7 and 20°C, the 3 chains react about 1.5 times faster than the a chains with the first CO molecule. In the presence of IHP, the a chains react about 1.5 times faster than the 3 chains, but the overall rate of the first CO binding is unchanged. These data emphasize the point seen in much of the NMR work that the nature of ligands and allosteric effectors plays an important role in the functional properties of Hb A. 

Santoro B, Chen S, Luthi A, et al. Molecular and functional heterogeneity of hyperpolarization-activated pacemaker channels in the mouse CNS. J Neurosci 2000 20 5264-5275. 

Biological media are inhomogeneous, and the simplest way to capture structural and functional heterogeneity is to operate at a molecular level. First, one has to model the time spent by each particle in the process and second, to statistically compile the molecular behaviors. As will be shown in Section 9.3.4, this compilation generates a process uncertainty that did not exist in the deterministic model, and this uncertainty is the expression of process heterogeneity. 

The variance expression is composed of two terms m0ps (t) generalizes the variance of a standard binomial distribution and is attributable to the stochastic transfer mechanism (structural heterogeneity) and rn pp (f) reflects the random nature of h (functional heterogeneity). 

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