Electron Paramagnetic Resonance EPR Characterization of Heterogeneously Functionalized Dendrimers

ELECTRON PARAMAGNETIC RESONANCE (EPR) CHARACTERIZATION OF HETEROGENEOUSLY FUNCTIONALIZED DENDRIMERS 

Line-broadening effects for nitroxide-functionalized dendrimers that have unreacted primary amines and line-broadening effects when a second isothiocyanate is reacted with the dendrimer do not vary significantly. One clear indication of 

Experiments with sequential additions of NCS-TEMPO plus other isothiocyanates indicate that end groups are randomly distributed in relation to one another using this methodology. Even mannose-functionahzed dendrimers appear to have a random end-group distribution (see below). As with any random population, it is possible that some carbohydrate-functionalized dendrimers wUl have higher activity in binding studies than other populations. 

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