Fragmentation activity

Schreiber A, Kaplan A, Austen K Inhibition by 62 ClINH of Hageman factor fragment activation of coagulation, fibrinolysis, and kinin generation. J Clin Invest 1973 52 1402-1409. 

Degeneration Mitochondrial permeability transition with membrane depolarization, cytochrome c release, and mitochondrial swelling and fragmentation activation of caspases and cell death pathway, endonuclease fragmentation of DNA with chromatin and nuclear condensation phosphatidyserine exposure on cell surface cytoskeletal disruption with membrane blebbing... 

Fragment Activity Profiler — http ,iVtriped.nih,.gav.i i hemblB/ [ChEMBL. rel a... 

Fig. 3 Screenshots of the Fragment Activity Profiler. Top Single-scaffold view displays activity profiles for a given scaffold versus individual targets (at a specified level of the ChEMBL target hierarchy). Bottom Pairwise view allows comparison of activity profiles of two scaffolds simultaneously...

Normal condition presiunes intact fuel element claddings. In this case fission-fragment activity of coolant is determined by either surface contamination of claddings... 

Lys °]LSK, with a threshold concentration value of 2.0 0.4 x 10" ° M, representing a retention of fully 65% of parent fragment activity and 430% of the activity of the full-length peptide ([Nle ]LSK). Thus, basicity at the 10 position is a critical factor for LSK-receptor site interaction. Conversely, [4-11,... 

Fig. 2 Brush border enzyme activity in primary rat proximal tubular cells (RPTC) as a function of age. RPTC were cultured in 35 mm culture dishes for 4,6,8,10, and 12 days. Cell homogenates were assayed for alkaline phosphatase activity (ALP) and gamma glutamyl transpeptidase activity (GGT). Values were correlated to homogenate protein content and are expressed as a fraction of isolated proximal tubular fragment activity/mg protein (day 0). Results are the mean of three culture dishes from two different primary preparations. Statistical significance from day 0 as analyzed by one way ANOVA with a Dunnett s post test is denoted by where p<0.05 and by where p<0.01...

The TRADD or FADD domains bind to adapter proteins in the cytosol and together they form of a death inducing signaling complex (DISC). This complex recruits caspase-8, one of a family of calcium ion-activated serine proteases (caspases) which cleave polypeptides on the C-terminal side of their aspartate residues. DISC activates caspase-8 to activate a Bcl-2 activator, BID (Fig. 13.1 Oa). The resultant tBid fragment activates effector Bcl-2 proteins on the endoplasmic reticular membrane and mitochondrial outer membrane. 

In addition to cleaving individual cellulose chains into small oligosaccharides, cellulases can also cleave cellulose particles into smaller particles. This activity is called fragmentation or short fiber formation. Quantitative studies of fragmentation utilized uniform sieved Avicel particles as the substrate and a particle counter to measure the number and size of the particles produced [111, 112]. Fragmentation activity could only be shown with particles larger than... 

On the other hand, even the recently prepared Herrmann-Beller catalystf still requires higher temperatures for efficient coupling rates of the Heck reaction. Interestingly, the complexation of chloroarenes with the Cr(CO)3 fragment activates the arene-chlorine bond considerably toward the oxidative addition. Thus, Cr(CO)3 complexed chloroarenes react about 15 times faster than iodoarenes in Pd-catalyzed cross-couphng reactions under mild conditions, in particular in Pd/Cu-catalyzed cross-couplings with terminal acetylenes in refluxing THF and/or tertiary amines (Scheme 36). ... 

Ontak Fusion protein Diphtheria toxin fragment Active (CD25) T-cell limphoma FDAapproved - ... 

Chemical species which cannot he put into bottles, cannot be subjected to any reversible phase transition, occur only in solutions or other special environments, have an extremely short half-life, only exist in excited stages, etc., may have a full claim to being a chemical species and may even claim to be a separate phase, but may or may not claim to be substances. If the species only exist in equilibrium with other species inside pure substances or solutions, it seems plausible to admit them as species, but not as substances. This includes radicals, reactive fragments, activated complexes, ligand-receptor complexes, etc. Whether (different kinds of) tautomers should be classified as separate substances or species is less obvious, (van Brakel 2012, 222)... 

Recent findings imphcate apoptosis in neuronal degeneration after ischaemic brain injury in animal models of stroke (Mattson et al. 2000). Apoptotic cascades involve increased levels of intraceUular oxyradicals and calcimn induction of expression of proteins such as Par-4 (prostate apoptosis response-4), which act by promoting mitochondrial dysfunction and suppressing antiapoptotic mechanisms mitochondrial membrane depolarisation, calcium uptake, and release of factors (e.g. cytochrome c) that ultimately induce nuclear DNA condensation and fragmentation activation of cysteine proteases of the caspase family activation of transcription factors such as AP-1 that may induce expression of killer genes . 

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