Fractional responser

Under these circumstances, the fractional response in a functional system can be derived from the expression... 

Miyamoto et al. (101) obtained four fractions from the seed coats of wheat which inhibited development of the wheat embryo. A component from one of the fractions responsible for 20% of the total inhibitor activity was crystallized but not identified. 

Hill plots are often used in pharmacology, where y may be either the fractional response of a tissue or the amount of a ligand bound to its binding site, expressed as a fraction of the maximum binding, and x is the concentration. It is sometimes found (especially when tissue responses are measured) that the Hill coefficient differs markedly from unity. What might this mean ... 

Particulate matter (PM) is associated with adverse human respiratory health effects. Although much research has focused on the fine particle component (PM2.5), recent results from the USC Children s Health Study suggest that the coarse fraction may also affect respiratory health in children. Specific components of the coarse fraction responsible for these effects have not been identified, but ambient endotoxin is a strong candidate, based on toxicologic and epidemiologic studies. This study is collecting... 

Figure 6.16 shows a clear transition between the low volume fraction response and that at higher volume fractions. Perhaps the major problem with a fractal model is that it underestimates the complexity of colloidal... 

Cleland JG, Peimell DJ, Ray SG, Coats AJ, Macfarlane PW, Murray GD et al. Myocardial viabiUty as a determinant of the ejection fraction response to carvedilol in patients with heart failure (CHRISTMAS trial) randomized controlled trial. Lancet 2003 362 14—21... 

The bioavailable fraction (responsible for the inhibition of bacterial bioluminescence) constituted only 3-8% of the total content of elemental sulfur in the sample... 

Under these circumstances, the fractional response in a functional system can be derived from the expression defining the amount of active-state receptor coupled to G-protein. This yields the following expression for response with a Hill coefficient of unity (see Section 6.8.4) ... 

The actual amount of receptor species (for example, [AR]) is given by the fraction of receptor species multiplied by the total number of receptors (pA = [AR]/[Rtot]) and defines fractional response (p = RESP/Emax) as... 

One of the chemical difficulties in this research has been to provide drugs which would prolong the pain control factor so as to reduce the need for repeated dosage and at the same time to ehminatc the fraction responsible for euphoria... If this could be done, the same result might follow as occurred with cocaine... rapid decline in the use of cocaine as an addiction drug after the discovery of novocaine... (Small et al. 1938)... 

It is not obvious from these results that the amount deposited of IHSS HA is higher than that of IHSS FA, as decribed by Jucker and Clark for hydrophobic membranes (Jucker and Clark (1994)). It may be that with hydrophilic membranes charge effects become more important. The flux ratio was lowest for HA and, therefore, further fouling studies were carried out with HA, since HA appeared to be the critical fraction responsible for fouling. 

While effective doses of 1 to 2 mg seem small, the total body pool of /3C can be estimated at 15 to 20 mg, with a total plasma pool of ateut 0.5 to 1 mg. In comparison with these pool sizes, a 2-mg effective dose is relatively large. In addition, the average daily effective dose of jSC from food sources is likely to be less than 1 mg, since matrix effects probably impair bioavailability of /3C to a larger extent than with supplements such as that used by van Vliet et al (1995). The minimum effective dose required to yield a significant TGR fraction response, taking into account the error associated with measurement, has not been determined, but is not likely to be much less than 1 mg. Consequently, use of unlabeled jSC, even coupled with use of the TGR fraction, is probably not well suited to study /3C uptake and metabolism at effective doses typically derived from dietary sources. 

The RNA of the particles has continued to be studied, not only from a physicochemical point of view 68-61), but also from a biochemical one. Smith and Doell 62), for example, have fractionated the RNA from mouse liver microsomes by means of the starch exchanger CATO-2 into four fractions, one of which showed amino acid acceptor activity, and might be the fraction responsible for the finding by previous workers (cf. 21,197, also cf. 46, 59) of amino acid incorporation into microsomal RNA. This finding opens the possibility of finding other minor RNA constituents in the... 

Successive experiments have been carried out therefore with purified rat brain microsomes incubated with radioactive SAM at different pH values, with the aim of examining the rate of labeling of lipid intermediates, such as PME and PDE, and of Ptd-choline. As known,microsomes represent in liver and other tissues the main subcellular fraction responsible for the metabolic pathway. 

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