Formic chloro

Formic acid behaves differently. The expected octadienyl formate is not formed. The reaction of butadiene carried out in formic acid and triethylamine affords 1,7-octadiene (41) as the major product and 1,6-octadiene as a minor product[41-43], Formic acid is a hydride source. It is known that the Pd hydride formed from palladium formate attacks the substituted side of tt-allylpalladium to form the terminal alkene[44] (see Section 2.8). The reductive dimerization of isoprene in formic acid in the presence of Et3N using tri(i)-tolyl)phosphine at room temperature afforded a mixture of dimers in 87% yield, which contained 71% of the head-to-tail dimers 42a and 42b. The mixture was treated with concentrated HCl to give an easily separable chloro derivative 43. By this means, a- and d-citronellol (44 and 45) were pre-pared[45]. 

A bismethyienedioxy group in a 4-chloro or 11 -keto steroid is stable to cleavage by formic acid or glacial acetic acid (100°, 6 h). The tetramethyl derivative is readily hydrolyzed (50% AcOH, 90°, 3-4 h, 80-90% yield). ... 

B) A solution of BB g of 5-chloro-2,4-disulfamylaniline in 1.1 liters of BB% formic acid was heated under reflux for 2 hours. After removal of 200 ml of solvent by distillation, one liter of water was added and the product collected, washed with water and dried. Crystallization from dilute alcohol afforded 6-chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide as colorless needles, MP 342.5° to 343°C, as described in U.S. Patent 2,BOB,194. 

Chloro-1.3-dihydro-5-phenyl-2H-1,4-benzodiazeplne-2-thione Formic acid hydrazide... 

Alternatively, hydration of the acetylenes in cold concentrated sulfuric acid, or with mercury(II) sulfate in formic acid, yields 1-aryl-3,4-dihydro-5//-2-benzazepin-5-ones which are isolated as their methylsulfonate salts.79 If, however, acetylene 4 is stirred with pyrrolidine at room temperature then cyclization is accompanied by amination to give 8-chloro-l-(2-chlorophenyl)-4-(pyrrolidin-l-yl)-3i/-2-benzazepine (5) in high yield. 

The polymer, (CsHB04)x, was prepd (together with some monomer) on passing ozone thru a chloro formic so in of cyclopentene. It Is a cryst compd, insol in org solvents reacts violently with coned sulfuric acid a powerful expl Reft 1) Beil 5, (30) 2) C.D. Harries H. 

Diallyldiozonide (1,5-Hexadienediozonide, Hexadien 1,5-diozonid in Ger). CgHi 0O6, syrupy, explds strongly on heating. Was prepd by Harries Turk by treating a cooled chloro formic soln of diallyl,... 

Dlphenyltstraozonide. Cj 2Hi 0012 colorl, very volatile crysts explds violently on heating. Prepd by treating a chloro formic soln of diphenyl with ozone... 

Trichloromethyl chloroformate Formic acid, chloro-, trichloromethyl ester (8) Carbonochloridic acid, trichloromethyl ester (9) (503-38-8)... 

Isobutyl chloroformate Formic acid, chloro-, isobutyl ester (8) Carbonochloridic acid, isobutyl ester (9) (543-27-1) S-tcrf-Butyl-L-cysteine ferf-butyl ester L-Cysteine, S-(l,l-dim-ethylethyl), 1,1-dimethylethyl ester (9) ( —) acetate (38024-19-0) hydrochloride (2481-11-0)... 

A mixture of the alcohol with formic acid rapidly self-heated, then reacted violently [1], A stirred mixture with cyanoacetic acid exploded violently after application of heat [2], Contact with acids causes self-condensation of the alcohol, which may be explosively violent under unsuitable physical conditions. The general mechanism has been discussed [3], The explosion hazards associated with the use of acidic catalysts to polymerise furfuryl alcohol may be avoided by using as catalyst the condensation product of 1,3-phenylenediamine and l-chloro-2,3-epoxypropane [4], See Nitric acid Alcohols (reference 6)... 

Formhydrazide, 24,13 Formic acid, 20, 66, 102 23, 43 Formic acid, chloro-, benzyl ester, 23, 13... 

A gas liquid chromatographic (GLC) method was described for determining residues of Bayer 73 (2-aminoethanol salt of niclosamide) in fish muscle, aquatic invertebrates, mud, and water by analyzing for 2-chloro-4-nitroaniline, a hydrolysis product of Bayer 73 [83]. Residues were extracted with acetone-formic acid (98 + 2), and partitioned from water samples with chloroform. After sample cleanup by solvent and acid base partitioning, the concentrated extract was hydrolyzed with 2N NaOH and H202 for 10 min at 95°C. The 2-chloro-4-nitroaniline was then partitioned hexane ethyl ether (7 + 3) and determined by electron capture GLC. Average recoveries were 88% for fish, 82% for invertebrates, 82% for mud, and 98% for water at 3 or more fortification levels. 

The synthesis of the /m-benzo-separated analogue 380 of the broad spectrum antibiotic fervenulin was reported (81JOC1699) in five steps from 7-chloro-2,4(l//,3//)quinazolinedione 374. Nitration of 374 gave 375, whose methylation gave 376. Pursuant to the synthesis of 380, 376 was converted into 377 with hydrazine and then formylated with formic acid to give 378 or converted to the ethoxymethylene derivative 379. Catalytic hydrogenation of 378 or preferably 379 gave 380. 

Fermentation, 22, 53 Ferric nitrate, 23, 20 Fieser s solution, 21, 110 Filter fabric, Pyrex glass, 22, 33, 65 Vinyon, 22, 33, 67 Filter paper, hardened, 22, 45 Fischer indole synthesis, 22, 98 Flash distillation, 21, 85 Flask, modified Claisen, 22, 11 Fluorescence of 9-aminoacridine hydrochloride, 22, 7 Formaldehyde, 20, 60 Formalin, 22, 66 Formic acid, 20, 66, 102 23, 43 Formic acid, chloro-, benzyl ester, 23, 13... 

The reaction of 6-bromo-7-chloro-2-hydrazinobenzothiazole 402 with formic acid gives the corresponding 11,2,4]triazolo[3,2-/dbenzothiazole derivative 403 (unreported yield) (Equation 78) <2000IJH275>, a particular and surprising reactivity that has some precedents <1971JOC10, 1985JHC831>. 

Mobile phase composition 1 = toluene-ethyl acetate-formic acid (30 10 10, v/v) 2 = toluene-ethyl acetate-formic acid (55 20 25, v/v) 3 = toluene-acetone-formic acid (7 6 1, v/v) 4 = benzene-ethyl acetate-formic acid (30 15 5, v/v) 5 = chloroform-methanol-formic acid (15 3 2, v/v) 6 = chloro-form-methanol-formic acid (147 30 23, v/v) 7 = Toluene-chloroform-acetone-formic acid (8 4 3 3, v/v) 8 = chloroform-methanol-formic acid (37 8 5, v/v) 9 = chloroform-methanol-formic acid (36 9 5, v/v) 10 = ethyl acetate-chloroform-formic acid (24 21 5, v/v) 11 = ethyl acetate-chloro-form-formic acid (23 21 6, v/v). 

Figure 4.7 Anion exchange separation of carboxylic acids in red wine. Column, Shodex C811, 100 cm x 7.6 mm i.d. eluent, 3 mM perchloric acid flow rate, 0.9 ml min-1 temperature, 60 °C detection, reaction detection using chloro-phenol red at 430 nm. Peaks 1, citric acid 2, tartaric acid 3, malic acid 4, succinic acid 5, lactic acid 6, formic acid and 1, acetic acid.

FIGURE 9 Moderately rapid gradient separation. Column XTerra MS C, IS, 4.6x 20mm 3.5p.m. Gradient 0 to 100% B over 4min,A 0.1% formic acid in water, B 0.1% formic acid in acetonitrile. Flow rate 3.0mL/min. Temperature 30°C. Detection UV at 254 nm. Instrument Alliance 2795 with 996 photodiode array detector. Compounds (I) acetanilide, (2) triamcinolone, (3) hydrocortisone, (4) 2-amino-7-chloro-5-oxo-5H-[l]benzopyrano[2,3-b]pyridine-3-carbonitrile, (5) 6a-methyl-17a-hydroxyprogesterone, (6) 3-aminofluoranthene, (7) 2-bromofluorene, (8) perylene, (9) naphtho(2,3-a)pyrene. 

Tetramethyl-/ -phenylenediamine has been obtained in low yield by the reaction of />-phenylenediamine with various alkylating agents such as methyl iodide, methanol in the presence of hydrochloric acid at 170-200°, or formaldehyde and formic acid. In addition it has been prepared by methylating / -dimethyl-aminoaniline using methanol in the presence of hydrochloric acid at 170 -200°, followed by treatment of the resulting salts with aqueous ammonia at 180 190°. In the most recent >ro-cedure, / -phenyIenediamine was alkylated with sodium chloro-... 

Following earlier studies of the oxidation of formic and oxalic acids by pyridinium fluoro-, chloro-, and bromo-chromates, Banerji and co-workers have smdied the kinetics of oxidation of these acids by 2, 2Tbipyridinium chlorochromate (BPCC) to C02. The formation constant of the initially formed BPCC-formic acid complex shows little dependence on the solvent, whilst a more variable rate constant for its decomposition to products correlates well with the cation-solvating power. This indicates the formation of an electron-deficient carbon centre in the transition state, possibly due to hydride transfer in an anhydride intermediate HCOO—Cr(=0)(0H)(Cl)—O—bpyH. A cyclic intermediate complex, in which oxalic acid acts as a bidentate ligand, is proposed to account for the unfavourable entropy term observed in the oxidation of this acid. 

Acetamido-4-amino-6-chloro-s-triazine, see Atrazine Acetanilide, see Aniline, Chlorobenzene, Vinclozolin Acetic acid, see Acenaphthene, Acetaldehyde, Acetic anhydride. Acetone, Acetonitrile, Acrolein, Acrylonitrile, Aldicarb. Amyl acetate, sec-Amyl acetate, Bis(2-ethylhexyl) phthalate. Butyl acetate, sec-Butyl acetate, ferf-Butyl acetate, 2-Chlorophenol, Diazinon. 2,4-Dimethylphenol, 2,4-Dinitrophenol, 2,4-Dinitrotoluene, 1,4-Dioxane, 1,2-Diphenylhydrazine, Esfenvalerate. Ethyl acetate, Flucvthrinate. Formic acid, sec-Hexyl acetate. Isopropyl acetate, Isoamyl acetate. Isobutyl acetate, Methanol. Methyl acetate. 2-Methvl-2-butene. Methyl ferf-butvl ether. Methyl cellosolve acetate. 2-Methvlphenol. Methomvl. 4-Nitrophenol, Pentachlorophenol, Phenol. Propyl acetate. 1,1,1-Trichloroethane, Vinyl acetate. Vinyl chloride Acetoacetic acid, see Mevinphos Acetone, see Acrolein. Acrylonitrile. Atrazine. Butane. 

Azidoformic esters such as 342 react with Cgg in a [2-tl] addition (Scheme 4.70), if the temperature is high enough to induce the loss of nitrogen prior to addition, otherwise a [3-1-2] addition can be observed (Section 4.3.2) [172, 395, 397]. Typical conditions include heating of the mixture in solvents such as tetrachloroethane [395, 397, 398], chloronaphfhalene [397] or toluene [396] at 110-160 °C. These conditions also afford multiple addition products [172]. To avoid potential hazard during purification of the azido formiates, they were also generated in situ in one pot by the reaction of chloro-formic ester with sodium azide [396]. 

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