For toxicology screening

Festing, M. F. (1987) Genetic factors in toxicology implications for toxicological screening. CritRev Toxicol 18, 1-26. 

A reverse-phase microbore HPLC method with photodiode-array detection and UV spectral library was developed for toxicological screening of various drugs in plasma including etodolac and its methyl ester [30]. Sample preparation involved addition of prazepam (internal standard) to 500 pL of plasma followed by addition of 30 pL of 1M sodium hydroxide and 5 mL of dichloromethane. After shaking the sample for 1 minute and centrifuging, the upper aqueous layer was discarded. The organic phase was evaporated and reconstituted with 50 pL methanol and 20 pL water ... 

We refer to LC-MS/MS methods that were used to investigate diffusion through bronchial tissue in vitro [74] and for toxicological screening [54], In addition, the misuse of ipratropium in equine sports was investigated by LC-MS [24],... 

Modern QqQ instruments equipped with high-end fast electronics, and accompanying optimized software allow to follow several hundreds of analytes in one run by MRM thus making this scan mode the method of choice for qualitative and quantitative analysis. Therefore, MRM was commonly applied to TTA and QTA analysis for quantification in PK (Table 5), distribution (Table 6), and biotransformation studies (Table 7) as well as for toxicological screening and evidence of drug abuse (Table 8). Specificities and remarkable characteristics of these fields of application are addressed in the following sections. 

In the following sections some requirements for toxicological screening tests applicable for paper and board are outlined, the presently available tests are briefly reviewed, and some examples of the actual applications of toxicological test to paper and board are given (section 15.5). 

Sadeg N, Francois G, Petit B, Dutertre-CateUa H, Dumontet M. Automated liquid-chromatographic analyzer used for toxicology screening in a general hospital 12 months experience. Clin Chem 1997 43 498-504. 

When a synthetic procedure is run for the first time at the bench, a satisfactory result is obtained only rarely. If the purpose of the experiment was to prepare a limited quantity, e.g. for spectroscopic characterization or for toxicological screening, it is probably of minor importance if the yield was low. If, on the other hand, the purpose was to check a new method, or to run a pilot experiment for larger-scale preparation, a poor yield is often a starting point for tedious work to develop the procedure. 

Tracqui, A. Kintz, P. Mangin, P. High-performance liquid chromatographic assay with diode-array detection for toxicological screening of zopiclone, zolpidem, suriclone and alpidem in human plasma. J.Chromatogr., 1993, 616, 95—103... 

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