Food-dependent exercise-induced anaphylaxis

Dohi, M., Suko, M., Sugiyama, H., Yamashita, N., Tadokoro, K., Juji, F., Okudaira, H., Sano, Y., Ito, K., and Miyamoto, T. (1991). Food-dependent, exercise-induced anaphylaxis A study on 11 Japanese cases. /. Allergy Clin. Immunol. 87, 34- 0. 

Miyake, T., Kawamori, J., and Yoshida, T. (1988a). Food-dependent exercise-induced anaphylaxis in childhood. /. ]pn. Pediatr. Soc. 92,1328-1332. 

Tanaka, S. (1994). An epidemiological survey of food-dependent exercise-induced anaphylaxis in kindergartners, schoolchildren and junior high school students. Asia Pac. ]. Public Health 7,26-30. 

Morita, E., Yamamura, Y., Mihara, S., Kameyoshi, Y., Yamamoto, S. 2000. Food-dependent exercise-induced anaphylaxis A report of two cases and determination of wheat y-gliadin as the presumptive allergen. Br J Dermatol 143 1059-1063. 

Romano, A., Di Fonso, M., Giuffreda, F., Papa, G., Artesani, M.C., Viola, M., Venuti, A., Palmieri, V., and Zeppilli, R, Food-dependent exercise-induced anaphylaxis Clinical and laboratory findings in 54 subjects, Int. Arch. Allergy Immunol, 125, 264-272, 2001. 

Anaphylactic reactions to celery have been reported, including two cases of food-dependent, exercise-induced anaphylaxis after ingestion of celery (Barg et al. 2008 Vilke 2002). One case of anaphylactic reaction to the drug oseltamivir (Tamiflu) occurred in a patient with celery-carrot-mugwort-spice syndrome (Hirschfeld et al. 2008). 

Barg, W., A. Wolanczyk-Medrala, A. Obojski, et al. 2008. Food-dependent exercise-induced anaphylaxis Possible impact of increased basophil histamine releasability in hyperosmolar conditions. /. Investig. Allergol. Clin. Immunol. 18(4) 312-315. 

ViUce, G.M. 2002. Food-dependent exercise-induced anaphylaxis. Prehosp. Emerg. Care 6(3) 348-350. 

Soyer, O.U., and B.E. Sekerel. 2008. Food dependent exercise induced anaphylaxis or exercise induced anaphylaxis Allergol. Immunopathol. (Madrid) 36(4) 242-243. 

Only nine allergic reactions to cuttlefish have been described (Caffarelli et ah, 1996 Ebisawa et ah, 2003 Shibasaki et ah, 1989). One patient was a 10-year-old female who experienced a severe reaction to ingestion of cuttlefish that was manifested by urticaria, angioedema, asthma, abdominal pain, laryngeal edema, and hypotension (Shibasaki et ah, 1989). SPT and RAST were positive. This patient reportedly tolerated octopus, clam, oyster, abalone, mussel, and scallop but reacted to crab and shrimp. Caffarelli et ah (1996) describe a 14-year-old female who had cuttlefish-dependent, exercise-induced anaphylaxis. Ebisawa et ah (2003) reported 7 cases of allergy to cuttlefish among a series of 305 pediatric cases of food allergy but provided no specifics on the circumstances or symptoms of these patients. 

Wheat is one of the foods most commonly responsible for allergic reactions in children and adults. Hypersensitivity reactions to ingested wheat protein sources typically occur within an hour and include cutaneous, gastrointestinal, and/or respiratory symptoms. These reactions are clinically distinct from other adverse reactions to wheat protein, including baker s asthma, an inhalant IgE-mediated reaction to wheat and other cereal grain flours celiac disease, a non-IgE-medi-ated enteropathy caused by wheat gliadin and wheat-dependent exercise-induced anaphylaxis. 

The role of atopy in anaphylaxis has not completely been resolved. On the one hand there is for example no evidence of a higher risk of severe reactions in venom-allergic patients. A recent study by Sturm et al. [38] indicated that patients with high total IgE levels predominantly developed mild to moderate reactions. By contrast, atopy may increase the risk and severity of systemic reactions in beekeepers and their family numbers [39]. On the other hand, atopy and in particular allergic asthma are risk factors for food allergy and therefore are also important risk factors for food-induced anaphylaxis. This is most likely also true for exercise-induced anaphylaxis, but also non-IgE-dependent anaphylaxis induced by NSAIDs or contrast media. 

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