Follicle-stimulating hormone suppression

Plasma prolactin levels are reduced with acute treatment and remain suppressed after 28 days of chronic treatment (Murphy et al. 1998). With acute treatment, no effects are seen on plasma luteinizing hormone or testosterone levels. However, chronic dietary 5% ginseng increases testosterone levels in male rats (Fahim et al. 1982). Chronic ginsenosides do not alter posterior pituitary hormones oxytocin and vasopressin (Zierer 1991). Similarly, human males administered ginseng extract showed an increase in plasma testosterone, dihydrotestosterone, follicle-stimulating hormone, and luteinizing hormone, but a decrease in prolactin (Salvati et al. 1996). 

Pharmacology A synthetic androgen derived from ethisterone, danazol suppresses the pituitary-ovarian axis by inhibiting the output of pituitary gonadotropins. Danazol depresses the output of both follicle-stimulating hormone (FSH) and luteinizing... 

Mechanism of Action A testosterone derivative that suppresses the pituitary-ovarian axis by inhibiting the output of pituitary gonadotropins. Causes atrophy of both normal and ectopic endometrial tissue in endometriosis. Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are depressed in fibrocystic breast disease. Inhibits steroid synthesis and binding of steroids to their receptors in breast tissues. Increases serum levels of esterase inhibitor. Therapeutic Effect Produces anovulation and amenorrhea, reduces the production of est rogen, corrects biochemical deficiency as seen in hereditary angioedema. 

Wickings EJ, Nieschlag E. Suppression of spermatogenesis over two years in rhesus monkeys actively immunized with follicle-stimulating hormone. Fertility Sterility 1980 34(3) 269-74. 

Anabolic Steroids in Humans There are several methods to indicate that testosterone has been administered to a male human. Natural testosterone production is controlled by a feedback mechanism involving the pituitary gland, and administration of testosterone will suppress the natural production of pituitary hormones such as luteinising hormone (LH) and follicle stimulating hormone (FSH). 

G18. Gottschall, P. E., Katsuura, G., and Arimura, A. Interleukin-1 beta is more potent than interleukin-1 alpha in suppressing follicle-stimulating hormone-induced differentiation of ovarian granulosa cells. Biochem. Biophys. Res. Common. 163, 764-770 (1989). 

Dexamethasone suppression test Estriol excretion Follicle-stimulating hormone Free thyroxine Gastrin Glucagon Glucose blood... 

---