Speed fingerprint

Military uses for lasers are abundant, from range-finding to guided munitions to laser aiming devices on firearms. Warfare has been revolutionized by the laser. Law enforcement uses lasers to lift hard-to-recover fingerprints and in laser radar speed guns. 

FIGURE 35.9 Typical fingerprint of a final batch-mixing process data obtained from a GK160SUK with fixed rotor speed (18/25 rpm). 

Swadesh, J. K., High-speed tryptic fingerprinting, Peptide Res., 3, 282, 1990. 

Figure 6 High-speed tryptic fingerprint. Horse cytochrome c was digested with trypsin and the peptide chromatographed in acetonitrile water 0.1% TFA at various temperatures and flow rates on a 15 x 0.2-cm PS-DVB column packed with 3-p, 300-A particles, (a) 26°C and 0.5 ml/min. (b) 42°C and 0.7 ml/min. (c) 70°C and 1.1 ml/min. Detection at 220 nm. Note that the resolution rises with the speed of separation.89 (From Swadesh, ]., BioTechniques, 9, 626, 1990. With permission.)...

We begin by bringing you up to speed on mechanisms and reminding you how to push electrons around with those curved arrows. We jog your memory with a discussion of substitution and elimination reactions and their mechanisms, in addition to free radical reactions. Next you review the structure, nomenclature, synthesis, and reactions of alcohols and ethers, and then you get to tackle conjugated unsaturated systems. Finally, we remind you of spectroscopic techniques, from the IR fingerprints to NMR shifts. The review in this part moves at a pretty fast pace, but we re sure you can keep up. 

Abourashed, E.A., Vanderplank, J.R., and Khan, LA., High-speed extraction and HPLC fingerprinting of medicinal plants-application to Passiflora flavonoids, Pharm. Biol, 40, 81, 2002. 

Fig. 15.14 Analytical techniques for time-resolved headspace analysis. An electronic nose can be used as a low-cost process-monitoring device, where chemical information is not mandatory. Electron impact ionisation mass spectrometry (EI-MS) adds sensitivity, speed and some chemical information. Yet, owing to the hard ionisation mode, most chemical information is lost. Proton-transfer-reaction MS (PTR-MS) is a sensitive one-dimensional method, which provides characteristic headspace profiles (detailed fingerprints) and chemical information. Finally, resonance-enhanced multiphoton ionisation (REMPI) TOFMS combines selective ionisation and mass separation and hence represents a two-dimensional method. (Adapted from [190])...

A good reference on the flow cytometry of DNA fragments is Kim Y, Jett JH, Larson EJ, et al. (1999). Bacterial fingerprinting by flow cytometry Bacterial species discrimination. Cytometry 36 324-332. The proposed technique for sequencing DNA is described in a paper by Jett JH, Keller RA, Martin JC, et al. (1989). High-speed DNA sequencing An approach based upon fluorescence detection of single molecules. J. Biomol. Struct. Dynamics 7 301-309. 

For example, disc speeds could be changed from 3,000 to 4,000, 4,000 to 5,000, and 5,000 to 6,000 rpm without upsetting the delicately balanced spin fluid density gradient needed for effective particle size analysis. This can not be done with the BLS. Note that for quantitative accuracy minor volume changes need to be accounted for after repeat injection. However, for qualitative analysis or "fingerprinting" this procedure is acceptable. 

The calculation of the pharmacophore fingerprints is fast and a reasonably large number of molecules can be handled. The speed of these calculations permits the user to readily add to the overall procedure more information about the target or active compounds as probes in the ligand based virtual screening. 

Pharmacophore Keys. Originally designed to speed pharmacophore query searching, pharmacophore keys are bitset fingerprints that indicate the presence or absence of given... 

Among many benefits of press instrumentation, formulation fingerprinting is perhaps the most obvious. Compressibility and ejection profiles, as well as dissolution and disintegration curves related to compression force, are unique for each formulation and can be used as a batch record. For process optimization, one can include compression or precompression force and speed factors in experimental design. Compactibility and ejection profiles can be used for excipient and lubricant evaluation. Other useful product development and optimization tools include response surface, Heckel, and force-thickness plots. 

The addition of the contains function allows a quicker comparison of the fingerprint of the desired substructure with the fingerprints stored in the table. The matches function is then used only for structures which have passed this initial test. Since the matches function is slower than the contains function, the overall speed of the search is faster than if the fingerprint comparison were not done. 

There is some overhead in the use of indexes, constraints, triggers, etc. as discussed here. The overhead is incurred when rows are inserted or updated in the table. However, the value of this approach is that the data in the table are well validated and can be searched more reliably and efficiently. Direct lookups of canonical or stereo SMILES is simple and quick because of the index on these columns. Using the fingerprint column speeds up substructure search. Tautomers can be readily selected using the column of simple graphs. 

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