Findings in CR Rodents

It is well known that dwarf animal models, including Ames mice [24] and minirats bearing an antisense GH transgene [25], live longer than their normal counterparts. Therefore, it has been suggested that the GH/IGF-1 

During glucose tolerance testing, the blood glucose concentration in rats increases to a peak value at 15 minutes and then returns to the basal (0 minutes) level in both AL and CR rats (Fig. 5A). However, the blood glucose concentration in AL rats gradually decreases from 15 to 90 minutes, whereas that in CR rats quickly returns to the basal level at 30 minutes [30]. 

McCarter and McGee [35] examined changes in the metabolic rate immediately after starting 40% restriction of food at 6 weeks of age and continued to examine it until 24 weeks of age. As shown in Fig. 6A, the metabolic rate 

It has been suggested that thyroid status is a possible major regulator of metabolic rate. Herlihy et al. [38] found that CR reduces the 24-hour mean serum triiodothyronine (T3) level, but not the thyroxine (T4) level. CR appears to have this action because it attenuates the circadian amplitude in the concentrations of both hormones. However, Snyder et al. [39] found no effect of CR on either T4 or T3 in young rats and no consistent effect of CR on age-related changes in the concentrations of these two hormones. 

Body Weight and Serum Lipids in Male Wistar Rats at 6 Months of Age 

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