Fetal tachycardia

Vanbesien J, Casteels A, Bougatef A, De Catte L, Foulon W, De Bock S, Smitz J, De Schepper J. Transient fetal hypothyroidism due to direct fetal administration of amiodarone for drug resistant fetal tachycardia. Am J Perinatol 2001 18(2) 113-6. 

Atropine is absorbed orally and crosses the placental barrier, whereupon it causes fetal tachycardia. Atropine has been used to examine the functional integrity of the placenta. 

Atropine is absorbed orally and crosses the placental barrier, whereupon it causes fetal tachycardia. Atropine has been used to examine the functional integrity of the placenta. Atropine toxicity is characterized by dry mouth, burning sensation in the mouth, rapid pulse, mydriasis, blurred vision, photophobia, dry and flushed skin, restlessness, and excitement. 

Allan LD, Chita SK, Sharland GK, Maxwell D, Priestley K. Flecainide in the treatment of fetal tachycardias. Br Heart J 1991 65(l) 46-8. 

Trotter A, Kaestner M, Pohlandt F, Lang D. Unusual electrocardiogram findings in a preterm infant after fetal tachycardia with hydrops fetalis treated with flecainide. Pediatr Cardiol 2000 21(3) 259-62. 

The beta-adrenoceptor agonist effect is sufficient to cause fetal tachycardia when isoxsuprine is given intravenously in late pregnancy, although one large survey suggested that it may be better tolerated by the mother (as regards cardiac and stimulant effects) than salbutamol (SED-12, 313). The fact that maternal blood... 

When salbutamol is used to arrest premature labor, effective doses are likely to produce mild fetal tachycardia (for example an increase of 20/minute) (23). In one case, supraventricular tachycardia occurred in the fetus in the 34th week of pregnancy after the mother had been treated with salbutamol digoxin with and without propranolol was ineffective, but amiodarone controlled the tachycardia (24). 

Theophylline crosses the placenta, resulting in potentially dangerous serum theophylline concentrations in the neonate (SEDA-5, 3). This is of practical importance, since 1.3% of pregnant women have asthma. Fetal tachycardia has been observed when maternal blood concentration... 

Anastasio GD, Harston PR. Fetal tachycardia associated with maternal use of pseudoephedrine, an over-the-counter oral decongestant. J Am Board Fam Pract 1992 5(5) 527—528. 

A survey of 172 nurse midwives indicated that 90 regularly used herbal preparations to stimulate labor. Of these 90, 64% reported using blue cohosh. Adverse events data included in the results of this survey did not separate black cohosh Actaea racentosa) and blue cohosh the adverse events reported for the two botanicals were nausea, increased meconium-stained fluid, and transient fetal tachycardia. The frequency of these events was not indicated (McFarlin et al. 1999). 

Terbutaline has been shown to prolong pregnancy but has not been associated with decreased neonatal morbidity.36 It is contraindicated for use in women with preexisting cardiac arrhythmia. Potentially serious adverse effects include pulmonary edema, cardiac arrhythmia, or myocardial ischemia in the mother. Reported fetal and neonatal adverse effects include tachycardia, hyperglycemia, and hyperinsulinemia.41... 

De Catte L, De Wolf D, Smitz J, Bougatef A, De Schepper J, Foulon W. Fetal hypothyroidism as a complication of amiodarone treatment for persistent fetal supraventricular tachycardia. Prenat Diagn 1994 14(8) 762-5. 

Jouannic J-M, Delahaye S, Fermont L, Le Bidois J, Villain E, Dumez Y, Dommergues M. Fetal supraventricular tachycardia a role for amiodarone as second-line therapy Prenatal Diagn 2003 23 152-6. 

Edwards A, Peek MJ, Curren J. Transplacental flecainide therapy for fetal supraventricular tachycardia in a twin pregnancy. Aust NZ J Obstet Gynaecol 1999 39(1) 110-12. 

D Souza D, MacKenzie WE, Martin WL. Transplacental flecainide therapy in the treatment of fetal supraventricular tachycardia. J Obstet Gynaecol 2002 22(3) 320-2. 

When ritodrine is used to alleviate fetal distress and surgical intervention (cesarean section), atropine premedication must be avoided. The vagolytic action of atropine is synergistic with the action of ritodrine, resulting in severe maternal tachycardia and systohc hypertension (6). 

Belhassen A, Vaksmann G, Francart C, Vinatier D, Patey P, Monnier JC. Interet de I amiodarone dans le traitement des tachycardies supraventriculaires foetales. A propos d une observation. [Value of amiodarone in the treatment of fetal supraventricular tachycardia. Apropos of a case.) J Gynecol Obstet Biol Reprod (Paris) 1987 16(6) 795-800. 

Adverse reactions Tachycardia, palpitations, flushing, anxiety, pulmonary edema Diplopia, fatigue, flushing, pulmonary edema. Toxic levels absent DTRs, respiratory depression and failure, cardiac arrest Headaches, tachycardia, flushing Bleeding fetal effects premature closure of ductus arteriosus, decreased renal function in preterm infants, increased IVH Minimal... 

Hypotension, fetal distress, tachycardia, headache, nausea, vomiting, local thrombophlebitis infusion site should be changed after 12 hr... 

Ritodrine is contraindicated in antepartnm hemorrhage, which demands immediate delivery eclampsia and severe preeclampsia intrauterine fetal death chorioamnionitis maternal cardiac disease pulmonary hypertension maternal hyperthyroidism and uncontrolled maternal diabetes mellitus. Overdosage with ritodrine may canse tachycardia (maternal and fetal), palpitations, cardiac arrhythmia, hypotension, dyspnea, nervousness, tremor, nansea, and vomiting. 

HUMAN HEALTH RISKS EPA RID 0.002 mg/kg/d Acute Risks nausea vomiting sweating dizziness headaches weight loss fatigue weakness rapid breathing tachycardia rise in body temperature rapid metabolism and excretion Chronic Risks cataracts skin lesions effect on bone marrow, CNS and cardiovascular system polyneuropathy fetal growth inhibition exfoliative. 

The compound atropine has been shown to rapidly cross the placenta (Kanto et al. 1981 Kivalo and Saarikoski 1977 Onnen et al. 1979) and has been used to test placental function in high-risk obstetric patients by producing fetal vagal blockade and subsequent tachycardia (Heilman and Fillisti 1965). Atropine has also been used to reduce gastric secretions before cesarean section with no fetal or neonatal effects observed (Diaz et al. 1980 Roper and Salem 1981). 

Neurodevelopment delay has been attributed to long-term amiodarone exposure in a child with fetal junctional reciprocating tachycardia and normal thyroid function [39" ]. A refractory persistent tachycardia was treated in utero with digoxin 0.5 mg/day until delivery and amiodarone 100 mg/day from 26 to 35 weeks of gestation. The baby was delivered at 38 weeks, weighed 3550 g, and had normal acid-base balance. 

Tachycardia recurred 28 hours after delivery and reverted to sinus rhythm with amiodarone and propranolol, which were continued for 24 months. The neurological disturbances appeared at the age of 12 months, when hypotonia and delayed motor milestones were recognized. At the age of 18 months, the child had mildly neurological development delay, with hypotonia, ataxia, and foot deformities. At 24 months, motor milestones were mildly delayed. The developmental quotient was 68. Electroencephalography and an MRI scan of the central nervous system were normal. At 30 months, the motor milestones were stiU delayed and there was speech development and language delay. Chromosome analysis was normal. After exclusion of aU possible cause, an indirect link between long-term amiodarone exposure during fetal and postnatal life and neurodevelopmental delay was proposed. 

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