Salbutamol Digoxin

When salbutamol is used to arrest premature labor, effective doses are likely to produce mild fetal tachycardia (for example an increase of 20/minute) (23). In one case, supraventricular tachycardia occurred in the fetus in the 34th week of pregnancy after the mother had been treated with salbutamol digoxin with and without propranolol was ineffective, but amiodarone controlled the tachycardia (24). 

Oral salbutamol (albuterol) causes a small reduction in serum digoxin levels. Beta agonists can cause hypokalaemia, which could lead to the development of digitalis toxicity. 

A study in 10 healthy subjects who had taken digoxin 500 micrograms daily for 10 days found that, 3 hours after taking oral salbutamol (albuterol) 3 to 4 mg, their serum digoxin levels had fallen by 0.23 nanograms/mL and their serum potassium levels had fallen by... 

Edner M, Jogestrand T. Oral salbutamol decreases serum digoxin concentration. EurJ Clin... 

Edner M, Jogesttand T, Dahlqvist R. Effect of salbutamol on digoxin pharmacokinetics. EurJ Clin Pharmacol ( 992) 42,197-201. 

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