Hemoglobin ferric

Harris, G. 1966. Low spin ferric hemoglobin complexes. Theoretica Chimica Acta 5 379-397. 

FIGURE 8.5 Multiple-sensor respirometry. Representative calibration traces of PNOS (thin line, left ordinate) and PHSS (thick line, right ordinate) operating simultaneously in PBS, pH 7.3 at 37°C, with 50pM DTPA in a closed chamber respirometer. After NO additions were made, the chamber solution was replaced with fresh buffer, to which Na2S stock solutions were then injected in a stepwise manner. The stable POS signal shown at 2 pM 02 demonstrates that the POS does not respond to NO or H2S. Injections of anoxic buffered NO and H2S stocks are shown with concentrations at arrows, as are additions of Lucina pectinata ferric hemoglobin I (metHb I), which stoichiometrically binds to H2S (after [41]). 

Di lorio EE. Preparation of derivatives of ferrous and ferric hemoglobin. Meth Enzymol 1981 76 57. 

The oxygen binding site (sometimes called the active site) is sensitive to mutations that allow oxidation of the heme iron and destroy its ability to bind oxygen. Hemoglobins with this type of mutation are called ferric-hemoglobins or met-hemoglobins (Hb M). ... 

First let us look at an interesting experiment which will only have a phenomenological interpretation until we examine a model of this molecule. We start with ferric hemoglobin A, the oxidized form of the normal hemoglobin that probably all of us have, consisting of two alpha chains... 

Figure 5. EFR spectra of a sample of high-spin ferric hemoglobin A (upper) and the same sample to which histidine has been added (middle), and hemoglobin H (lower)...

The red cell has a system of reducing enzymes (38). It gets reducing equivalents from glucose and eventually these are converted to DPNH. There is a reductase which runs on DPNH and recognizes the ferric hemoglobin molecules which do not have their tertiary structure disrupted. There are cases where hemichromes will proceed to the irre-... 

Gibson and Ingram (14) measured the principal g-values in (ferric) hemoglobin azide. They found (Table 2). 

Methemoglobinemia occurs when oxidants [e.g., nitrates (in ruminants), nitrites, copper, chlorates, acetaminophen (in cats)] change ferrous hemoglobin to ferric hemoglobin, interfering with the ability of heme to accept oxygen. 

Mulks CF, Scholes CP, Dickinson LC, Lapidot A. 1979. Electron nuclear double resonance from high- and low-spin ferric hemoglobins and myoglobins. J Am Chem Soc 101(7) 1645-1654. 

Fio. 18. Relation between the magnetic moment in Bohr magnetons and the absorption maximum in the Soret region of various horse ferric hemoglobin complexes values from reference (197) and O values from (198). 

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