Fenton, Henry

Fenton, Henry John Horstman (1854-1929) British chemist at Cambridge in 1878 and was University Lecturer in chemistry from 1904 to 1924. 

The reaction was reported by Henry J. Fenton [140]. This reaction is appHed in the treatment of hazardous organic wastes. A search for Fenton reaction in the website ISI Web of Knowledge [141] throws up thousands of scientific papers due to the exponential growth in its use over the years. It has been reviewed in various papers [142-145]. Below, the reaction pathway in the absence of an organic compound is given ... 

W.H.M. [Mills, W. H.] (1930). Obituary notices Henry John Horstman Fenton. Proceedings of the Royal Society of London, Series A 127 i-v. 

The iron(II) ion (Fe " ) reduces hydrogen peroxide to hydroxyl radical and hydroxide ion. The mixture of H2O2 and Fe + is known as Fenton s reagent. It was developed in the 1890s by Henry John Horstman Fenton. The effective oxidizing agent is the hydroxyl radical (HO-). 

The generation of -OH in the very close proximity required for its interaction with DNA is believed to transpire by the Fenton reaction (1), first described around the turn of the nineteenth century by Henry John Horstman Fenton, who discovered that hydrogen peroxide is a much more potent oxidant in the presence of various metals, notably the ferrous ion (Fell) than in their absence. Subsequently, Fritz Haber and coworkers proposed that the potent oxidant generated during the Fenton reaction is in fact -OH, produced according to the following reaction (18) ... 

Oxidative damage (stress) in vivo is often ascribed to the Fenton reaction. In 1876, Henry Fenton described a colored product obtained by mixing tartaric acid with hydrogen peroxide and a low concentration of a ferrous salt (Fenton 1876) and found that iron acts catalytically (Fenton 1894). Haber and Weiss (1932, 1934) proposed the involvement of free hydroxyl radicals in the iron(II)/hydrogen peroxide system (called Fenton chemistry) ... 

In 1876, Henry J.H. Fenton publicly announced that the use of a mixture of H2O2 and Fe " (thereafter so-called Fenton s reagent) allowed the destruction of an organic compound, namely, tartaric acid [1], Such discovery triggered an intense research to elucidate the mechanistic fundamentals and propose different variants and applications of the Fenton process. The possible formation of Fe(IV) as an active Fenton intermediate, as well as the modeling of the real structure of the iron aqua complexes, is still the subject of discussion [2, 3]. However, at present, it is quite well established that the classical Fenton s reaction (1) involves the production of highly oxidative hydroxyl radicals ( OH) in the bulk as the main reactive species, and its optimum pH value is 2.8-3.0 [1] ... 

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