FEMALE REPRODUCTIVE BIOLOGY

Bretveld, R.W., Thomas, C.M.G., and Scheepers, P.T.J. et al. (2006). Pesticide exposure the hormonal function of the female reproductive system disrupted Reproductive Biology and Endocrinology 4. 

Numerous diagnostic methods have been developed to evaluate female reproductive dysfunction. Although these methods have rarely been used for occupational or environmental toxicological evaluations, they may be helpful in defining biological parameters and mechanisms related to female reproductive toxicity. If clinical observations link exposure to the reproductive effect of concern, these data will aid the assessment of adverse female reproductive toxicity. The following clinical observations include end-points that may be reported in case reports or epidemiological research studies. 

Choi KC, Leung PC, Jeung EB. 2005. Biology and physiology of Calbindin-D9k in female reproductive tissues involvement of steroids and endocrine disruptors. Reprod Biol Endocrinol 3 66. 

Fukaya, M. and Honda, H. (1995). Reproductive biology of the yellow-spotted longicom beetle, Psacothea hilaris (Pascoe) (Coleoptera Cerambycidae). 2. Evidence for two female pheromone components with different functions. Appl. Entomol. Zool., 30, 467 170. 

The prostaglandins occur in all tissues but in very small amounts. They act on loci in the same cells as those in which they are synthesized, and their biological roles are diverse e.g., they function in the female reproductive system during ovulation, menstruation, pregnancy, and parturition, and they stimulate uterine muscle contraction. 

Lamperti AA, Printz RH. 1973. Effects of mercuric chloride on the reproductive cycle of the female hamster. Biology of Reproduction 8 378-387. 

Compounds that produce the same biological effects as progesterone are called progestins [1], These effects are mediated by the progesterone receptor (PR), which is an important drug target due to its prominent role in the female reproductive cycle. 

Fig. 10.2 Cellular response to LPA and SIP in different organ systems. Examples of receptor-mediated cellular responses to LPA and SIP. Cytoskeletal reorganization, migration, survival, and proliferation operate in many biological systems particularly within the nervous system, the cardiovascular system, the immune system, and the female reproductive system. IL-2, interleukin-2 VEC, vascular endothelial cells VSMCs, vascular smooth muscle cells eNOS, endothelial nitric oxide synthase...

Overstreet JW, Katz D. 1990. Interaction between the female reproductive tract and spermatozoa, in Gagnon C, Ed. Controls of Human Sperm Motility Biological and Clinical Aspects. Boca Raton, FL CRC Press, pp. 64—75. 

Pames S, Raviv S, Sagi A (2008) Male and female reproduction in penaeid shrimps. In Mente E (ed) Reproductive biology of crustaceans case studies of decapod crustaceans. Science Publishers, Enfield, pp 365-390... 

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