Feeding behaviour

Appetite control is a complex function of the brain that regulates feeding behaviour. This function integrates cognitive and emotional factors with a complex array of signals from the gastrointestinal tract and from adipose tissue. 

MC4R for feeding behaviour, targeting one or both of these recqDtors in addition to understanding the complex cross-talk within the CNS may lead to the development of melanocortin based therapeutics for the treatment of eating disorders [5]. 

In additon to the central role of endocannabinoids in the regulation of feeding behaviour, a peripheral role has also been described. Gomez and coworkers [360] reported that food deprivation produced a 7-fold reduction in (1) levels in the small intestine of rats, but not in the brain or stomach. Intestinal (1) levels returned to normal when feeding resumed. The authors also showed that peripheral, but not central administration of (382) reduced food intake. The endocannabinoid system has also been reported to regulate peripheral lipogenesis [361]. 

Graves B.M. and Halpem M. (1990). Roles of vomeronasal organ chemoreception in tongue flicking, exploratory and feeding behaviour of the lizard Chacides ocellatus. Anim Behav 39, 692-698. 

Mathers, R.A., J.A. Brown, and P.H. Johansen. 1985. The growth and feeding behaviour responses of large-mouth bass (Micropterus salmoides) exposed to PCP. Aquat. Toxicol. 6 157-164. 

McGlone, J.J. and Anderson, D.L. (2002) Synthetic maternal pheromone stimulates feeding behaviour and weight gain in weaned pigs. J. Anim. Sci 80, 3179-83. 

Borell EM, Foggo A, Coleman RA (2004) Induced resistance in intertidal macroalgae modifies feeding behaviour of herbivorous snails. Oecologia 140 328-334... 

Similar to fish, PFOS is the dominant PFC found in aquatic invertebrates such as shrimp, mussels, clams and oysters [132,133]. A few papers report on PFC levels in bivalves. Concentration ranging from 1 to 6.0 ng/g wwt) in oysters were reported from the Ariake Sea [134] and China [133], respectively. Cunha et al. [135] measured high concentrations of PFOS in mussels from several estuaries in the North of Portugal. PFOS was detected in all the samples analysed, and the concentrations were ranging 36.8 to 126.0 ng/g wwt. In a more recent work, Nania et al. [130] found higher PFOA than PFOS in clam but comparable levels were found in mussels, which were attributed to differences in habitat and feeding behaviour. 

Brito B, Castro R, Cabrera de Leon A, Oleoylethanolamide A molecular crosstalk with leptin in feeding behaviour regulation, Lett Drug Des Disc 5 741—746, 2006. 

Menaker That s true, but we haven t done that. The other thing we must remember is that in our hands the peak of Per expression in the liver varies a good deal from one experiment to another. This has to do with how the rats are responding to the immediate situation that they are in. We need to start measuring feeding behaviour, because they feed at different times under somewhat different circumstances. This changes with age, too. The right way to do your experiment is to get the V er expression and the RNA from the same animals. 

Menaker Have you measured feeding behaviour in the Vpac2 knockout mice ... 

Gonzales, W.L. et al.. Host plant changes produced by the aphid Sipha flava consequences for aphid feeding behaviour and growth, Entomol. Exp. Appl., 103, 107, 2002. 

Hughes, B.O. (1984) The principles underlying choice feeding behaviour in fowls -with special reference to production experiments. World s Poultry Science Journal 40, 141-150. 

Feeding behaviour 5-HT1A agonists enhance food consumption in experimental animals... 

Kvitek, R., DeGange, A. R., and Beitler, M. K., Paralytic shellfish poisoning toxins mediate feeding behaviours of sea otters, Limnol. Oceanog., 36, 393, 1991. 

Furostanol-type steroid saponins in fenugreek increased food intake in normal rats significantly, while modifying the circadian rhythm of feeding behaviour in diabetic rats resulted in a progressive weight gain in contrast to untreated diabetic controls. In normal and diabetic rats, steroid... 

Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richarson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M (1998) Orexin and orexin receptors a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 92 573-585. 

The physiological basis of the effects of cannabinoids on feeding behaviour is not known. A French group has reported that neurons in the solitary tract nucleus, which respond to increases in glucose concentrations, are sensitive to zl9-THC and have suggested that such neurons may mediate canna-binoid effects on feeding behaviour [129]. 

Neuropeptide Y (NPY) receptors are a class of G-protein-coupled receptors that are activated by the closely related peptide hormones NPY, peptide YY and pancreatic polypeptide. These receptors are involved in control of a diverse set of behavioural processes, including appetite, circadian rhythm and anxiety. AgRP is a receptor antagonist of CNS melanocortin receptors and appears to have an important role in the control of food intake. Hypothalamic POMC neurons are important mediators in the regulation of feeding behaviour, insulin levels and ultimately body weight. 

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