FceRI expression

Hamilton RG, Lichtenstein LM Down-regulation of FceRI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody. J Immunol 1997 158 ... 

Fujimura Y, Tachibana H, Yamada K. 2004. Lipid raft-associated catechin suppresses the FceRI expression by inhibiting phosphorylation of the extracellular signal-regulated kinasel/2. FEBS Lett 556 204-210. 

Shim, S. Y., Choi, J. S., and Byun, D. S. (2009a). Inhibitory effects of phloroglucinol derivatives isolated from Ecklonia stolonifera on FceRI expression. Bioorg. Med. Chem. 17, 4734-4739. 

Shim, S. Y., Le, Q. T., Lee, S. H., and Kim, S. K. (2009b). Ecklonia cava extract suppresses the high-affinity IgE receptor, FceRI expression. Food Chem. Toxicol. 47, 555-560. 

Mediator Release from Basophils and Mast Cells and Its Relationship to FceRI Expression and IgE-Suppressing Therapies... 

We now know, however, that the concentration of IgE antibody also determines the expression of FceRI on basophils and mast cells (see below), although a direct demonstration of this observation on human tissue mast cells has not yet been made. Thus, if IgE titers fall, so too does FceRI expression. This dynamic considerably alters the prediction made above. Much more modest and achievable changes in IgE titer, 50- to 100-fold, significantly reduce the function of basophils. The details of this prediction are borne out in therapeutic trials of anti-IgE antibody. 

III. FceRI Expression on Basophils and Mast Cells A. Descriptives... 

Surface FceRI expression on peripheral blood eosinophils has been variably observed in vivo since the first report of the high-affinity receptor on blood eosinophils (90) and remains a topic of controversy (91). The initial description involved blood eosinophils from subjects with hypereosinophilic syndromes (90), but subsequent studies have failed to reproduce these observations (85,92). Blood eosinophils express both mRNA and intracellular protein for the a and y subunits of the FceRI receptor complex but lack the P subunit protein. Eosinophils in culture with IL-5 release the a subunit protein into the culture supernatant, but the addition of IgE failed to induce expression of the receptor on the cell surface... 

Lantz CS, Yamaguchi M, Oettgen HC, Katona IM, Miyajama I, Kinet JP, Gafii SJ. IgE regulates mouse basophil FceRI expression in vivo. J Immunol 1997 158 2517-2521. 

Yamaguchi M, Lantz CS, Oettgen HC, Katona IM, Fleming T, Miyajama L Kinet JP, GaUi SJ. IgE enhances mouse mast cell FceRI expression in vitro and in vivo evidence for a novel amplification mechanism in IgE-dependent reactions. J Exp Med 1997 185 663-672. 

Ryan JJ, DeSimone S, Klisch G, Shelburne C, McReynolds LJ, Han K, Kovacs R, Mirmonsef P, Huff TF. IL-4 inhibits mouse mast cell FceRI expression through a STAT6-dependent mechanism J Immunol 1998 161 6915-6923. 

Xia HZ, Du Z, Craig S, Khsch G, Noben-Trauth N, Kochan JP, Huff TH, Irani AM, Schwartz LB. Effect of recombinant human IL-4 on Iryptase, chymase, and FceRI expression in recombinant human stem cell factor- dependent fetal Uver-derived human mast cells. J Immunol 1997 159 2911-2921. 

Yamaguchi M, Sayama K, Yano K, Lantz CS, Noben-Trauth N, Ra C, Costa JJ, Galli SJ. IgE enhances FceRI expression and IgE-dependent release of histamine and lipid mediators from human umbilical cord blood- derived mast cells synergistic effect of IL-4 and IgE on human mast cell FceRI expression and mediator release. J Immunol 1999 162 5455-5465. 

Reischl IG, Corvaia E, Effenberger F, WoR-Winiski B, Kromer E, Mudde GC. Function and regulation of FceRI expression on monocytes from non-atopic donors. Clin Exp Allergy 1995 26 630-641. 

Since it has been shown that FceRI, expressed by professional antigen-presenting cells such as human epidermal Langerhans cells (73), dendritic cells (6), and monocytes (74), was able to very efficiently mediate antigen capture, processing, and presentation, eosinophils might possibly fulfill the same function. 

Tanaka Y, Takenaka M, Matsunaga Y, Okada S, Anan S, Yoshida H, Ra C. High affinity IgE receptor (FceRI) expression on eosinophils infiltrating the lesions and mite patch tested sites in atopic dermatitis. Arch Dermatol Res 1995 287 712-771. 

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