European Prospective Investigation EPIC

Al-Delaimy, W.K. et al., Plasma levels of six carotenoids in nine European countries report from the European Prospective Investigation into Cancer and Nutrition (EPIC), Public Health Nutr., 1, 713, 2004. 

Zamora-Ros R, Andres-Lacueva C, Lamuela-Raventos RM, Berenguer T, Jakszyn P, Martinez C, Sanchez MJ, Navarro C, Chirlaque MD, Tormo MJ, Quiros JR, Amiano P, Dorronsoro M, Larranaga N, Barricarte A, Ardanaz E and Gonzalez CA. 2007. Concentrations of resveratrol and derivatives in foods and estimation of dietary intake in a Spanish population European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain cohort. Br J Nutr 100(1) 188-196. 

European Prospective Investigation into Cancer and Nutrition (EPIC) Large study (over 500,000 participants) designed to investigate relationship between diet, nutritional status, lifestyle, and environmental factors and incidence of cancer and other chronic diseases. Blood samples are banked for future analyses (IARC 2005). 

The European Prospective Investigation into Cancer and Nutrition (EPIC) is the largest study of diet and health in the EU, with over 520,000 participants in 10 European countries. The study, initiated in 1992, collects detailed information and diet and lifestyle factors in addition to blood samples, which are stored for future analyses. The study participants will be followed for the next 10 years to investigate the role of nutrition in the development of chronic disease (IARC 2005). 

I ARC (International Agency for Research on Cancer). 2005. European Prospective Investigation into Cancer and Nutrition. International Agency for Research on Cancer, World Health Organization, Lyon, France [online]. Available http //www.iarc.fr/epic/Sup-default. html [accessed Sept. 26, 2005]. 

EPIC European Prospective Investigation into Cancer and Nutrition. 

Boekholdt SM, Kuivenhoven JA, Wareham NJ, Peters RJ, Jukema JW, Luben R, Bingham SA, Day NE, Kastelein JJ, Khaw KT. Plasma levels of cholesteryl ester transfer protein and the risk of future coronary artery disease in apparently healfliy men and women the prospective EPIC (European Prospective Investigation into Cancer and nutrition)-Norfolk population study. Circulation 2004 110 1418-1423. 

Khaw KT, Wareham N, Luben R, Bingham S, Oakes S, Welch A, et al. Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of European prospective investigation of cancer and nutrition (EPIC-Norfolk). BMJ 2001 322 15-8. 

Khaw, K.T., Bingham, S., Welch, A., Luben, R., Wareham, N., Oakes, S., and Day, N., European Prospective Investigation into Cancer and Nutrition relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study a prospective population study. Lancet, 357, 657,2001. 

But even if one were to accept the epidemiologic data at face value and assume that the entire correlation was due to a causal link flowing in only one direction (from alcohol to breast cancer), how strong is that association anyway The largest study to bear on that question is the European Prospective Investigation into Cancer and Nutrition (EPIC). It examined data collected on self-reported alcohol consumption and cancer diagnoses in 274,688 middle-aged and elderly women from ten countries for up to 9.4 years (median 6.4 years). 

Drogan, D., Klipstein-Grobusch, K., Dierkes, J., Weikert, C., and Boeing, H., 2006. Dietary intake of folate equivalents and risk of myocardial infarction in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study. Public Health Nutrition. 9 465-471. 

Forouhi, N. G., Ye, Z., Rickard, A. R, et al. 2012. Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes Results from the European Prospective Investigation into Cancer (EPIC)-NorfoIk cohort and updated meta-analysis of prospective studies. Diabetologia, 55(8) 2173-82. 

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