Etodolac

Molecular formula Ci7H2iN03 Molecular weight 287.4 CAS Registry No. 41340-25-4 

Sample preparation 2 mL Whole blood or plasma -I- 2 mL buffer -I- 5 mL chloroform isopropanol n-heptane 60 14 26, shake gently horizontally for 10 min, centrifuge at 2800 g for 10 min. Remove the lower organic layer and evaporate it to dryness under vacuum at 45°, reconstitute the residue in 100 p,L mobile phase, centrifuge at 2800 g for 5 min, inject a 50 p,L aliquot of the supernatant. (Buffer was saturated ammonium chloride solution 25% diluted with water, adjusted to pH 9.5 with 25% ammonia solution.) 

Mobile phase MeOH THF buffer 65 5 30 (Buffer was 0.68 g/L (10 mM (sic)) KH2PO4 adjusted to pH 2.6 with concentrated orthophosphoric acid.) (At the end of each session wash the column with water for 1 h and MeOH for 1 h, re-equilibrate for 30 min.) 

Tracqui, A. Kintz, R Mangin, P. Systematic toxicological analysis using HPLC/DAD. J.Forensic Sci., 1995, 40, 254-262 

Sample preparation 1 mL Serum or plasma + 4 mL 1 M HCl + 5 mL hexane isopentyl alcohol 95 5, shake mechanically for 15 min, centrifuge at 1000 rpm for 5 min. Remove a 4 mL aliquot of the organic layer and add it to 1 mL 100 mM pH 11.0 Tris buffer, shake mechanically for 15 min. Remove an 800 xL aliquot of the aqueous layer and add it to 20 p,L 2.5 M phosphoric acid, inject a 50-150 p-L aliquot. 

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Equilibrium expression, 19 Equimolar potency ratios, 200-201 Etodolac, 154f Evaporation rate, 10, 12 Exemestane, 163f Experiment(s)... 

NSAIDs are of diverse chemical structures salicylates (aspirin, sulphasalazine), indole acetic acids (indomethacin, etodolac), heteroaryl acetic acids (diclofenac), arylpropionic acids (ibuprofen, naproxen), anthranilic acids (mefenamic acid) and enolic acids (piroxicam, meloxicam). 

CjH N 57 -54-/) see Etodolac ethyl 3-anilinocarbanilate (C15H16N2O2 37711-28-7) see Moracizine ethyl anthranilate... 

QH12N2 19275-55-9) see Etodolac ethylphenylmalondiamide (C11H14N2O2 7206-76-0) see Primidone ethylphenylmalonic acid diethyl ester see under diethyl cthylphenylmalonate... 

Acetic acid Etodolac 300-600 mg twice daily 400-1 000 mg once daily (extended-release) 1200... 

Pyranocarboxylic acid Etodolac (various) (immediate release) Acetic acid 7.3 200-400 q 6-8 h 1,000... 

This report presents various methods developed primarily at our laboratory for chromatographic resolution of racemates of several pharmaceuticals (e.g., -blockers, NSAIDS, anta-acids, DL-amino acids, Bupropion, Baclofen, Etodolac, Carnitine, Mexiletine). Recently, we developed methods for establishing molecular dissymmetry and determining absolute configuration of diastereomers (and thus the enantiomers) of (/< .S )-Baclofcn, (/d.SJ-Bctaxolol with complimentary application of TLC, HPLC, H NMR, LCMS this ensured the success of diastereomeric synthesis and the reliability of enantioseparation. 

Ibuprofen, naproxen, etodolac 2-phenoxypropionic acid, dichlorprop, 2-... 

Rodriguez de Pablos, R., Garcia-Ruiz, C., Crego, A. L., and Marina, M. L. (2005). Separation of etodolac enantiomers by capillary electrophoresis. Validation and application of the chiral method to the analysis of commercial formulations. Electrophoresis 26(6), 1106—1113. 

Ethinyl Estradiol 74 Ethmozne 50 Ethynodiol Diacetate 74 Etidonate 34 Etodolac 34 Etretinate ... 

Miid to moderate pain (diclofenac potassium, etodolac, fenoprofen, ibuprofen, ketoprofen, ketorolac, meclofenamate, mefenamic acid, naproxen, naproxen... 

Many NSAIDs inhibit both COX-1 and COX-2. Most NSAIDs are mainly COX-1 selective (eg, aspirin, ketoprofen, indomethacin, piroxicam, sulindac). Others are considered slightly selective for COX-1 (eg, ibuprofen, naproxen, diclofenac) and others may be considered slightly selective for COX-2 (eg, etodolac. 

Category C (etodolac, ketorolac, mefenamic acid, meloxicam, nabumetone, oxaprozin, tolmetin, piroxicam, celecoxib). All NSAIDs are Category D if used in the third trimester or near delivery. Avoid during pregnancy, especially in the third trimester. 

Drug/Food interactions Administration of tolmetin with milk decreased total tolmetin bioavailability by 16%. When tolmetin was taken immediately after a meal, peak plasma concentrations were reduced by 50%, while total bioavailability was again decreased by 16%. Peak concentration of etodolac is reduced by about 50% and the time to peak is increased by 1.4 to 3.8 hours following administration with food however, the extent of absorption is not affected. Food may reduce the rate of absorption of oxaprozin, but the extent is unchanged. 

CNS Dizziness (mefenamic acid, meloxicam, piroxicam, flurbiprofen, diciofenac, fenoprofen) headache (ketorolac, fenoprofen, indomethacin, diclofenac, flurbiprofen, meclofenamate, meloxicam, nabumetone, naproxen, tolmetin, ketoprofen, sulindac, celecoxib, mefenamic acid, piroxicam, ibuprofen) somnolence/drowsiness (fenoprofen, naproxen) asthenia (tolmetin, etodolac) malaise (etodolac) fatigue (indomethacin) insomnia (meloxicam). Dermatologic Rash/dermatitis, including maculopapular type (ibuprofen, sulindac, meclofenamate, oxaprozin, nabumetone, mefenamic acid, meloxicam) desquamation angioneurotic edema ecchymosis petechiae purpura alopecia pruritus (nabumetone, naproxen) eczema skin discoloration hyperpigmentation skin irritation peeling skin eruptions (naproxen). 

Other- Gastritis (etodolac) pyrosis (meclofenamate) heartburn (naproxen, meclofenamate, ibuprofen, mefenamic acid, piroxicam) Gl distress (tolmetin) epigastric pain (ibuprofen) indigestion (ibuprofen) Gl tract fullness (ibuprofen) Gl pain (sulindac) gross bleeding (mefenamic acid). 

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