Etodolac, properties

Etodolac Lodine Effective as analgesic/anti-inflammatory agent with fewer side effects than most NSAIDs may have gastric-sparing properties. 

The pharmacokinetics of etodolac have been extensively studied [4, 37-38]. Etodolac possesses a chiral center, and it has been established that the (S)-(+)-etodolac enantiomer possesses almost all of the anti-inflammatoiy property. Pharmacokinetic properties of the non-stereospecific and stereospecific etodolac are described in the following sections... 

It is a nonsteroidal antiinflammatory agent that possesses analgesic, antipyretic, and antiinflammatory properties. The most common side effects of etodolac are dyspepsia, abdominal pain, diarrhea, flatulence, nausea, vomiting, gastritis, or constipation (see also Table 3). 

Demerson, C.A. Humber, L.G. Abraham, N.A. Schilling, G. Martel, R.R. Pace-Asciak, C. Resolution of etodolac and antiinflammatory and prostaglandin synthetase inhibiting properties of the enantiomers. J.Med.Chem., 1983, 26, 1778—1780... 

NSAIDs can be classified on the basis of their COX inhibitory and selectivity properties. In general, most NSAIDs inhibit both COX-1 and COX-2 to some extent, but most are mainly COX-1-selective (e.g., aspirin, sulindac, indomethacin, ketoprofen, piroxicam) some are somewhat selective for COX-1 (e.g., ibuprofen, diclofenac, naproxen) others are slightly selective for COX-2 (etodolac, meloxicam) while NSAIDs like luntiracoxib, rofecoxib, and cele-coxib are clear selective inhibitors of COX-2 (Fig. 9.3). Clearly, knowing the relative inhibitory potencies of different NSAIDs for COX-1 and COX-2 would be useful in attempting to... 

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