1- Ethoxy-2-butanone

C(CH3)j CHj ch3 ch3 czh5 3-tert.- Butylamino-2,2-di-methoxy-butan 3-tert.-Butylamino-2,2-di-ethoxy-butan 81 33 3-tert. -Butylamino-2-butanon 65 ... 

Diazomethane is prepared as described in Org. Synth., Coll. Vol. /V1963, 250, with 50 g of Diazald (from Aldrich Chemical Company, Inc.) in 300 mL of ether added to 15 g of KOH in 25 mL of water, 30 mL of ether, and 50 mL of 2-(2-ethoxy-ethoxy)ethanol. One equivalent of diazomethane becomes incorporated in the reaction product, and the remainder serves as a scavenger for the HCI produced as a reaction by-product. The excess of diazomethane called for in this procedure is necessary to inhibit the undesired formation of 1-chloro-4-phenyl-2-butanone. The submitters report that this reaction can be performed on twice this scale with comparable results. 

Adhesive (liquid, all purpose) acetone, methylacetate, ethylacetate, 8 2-butanone, 1 -ethoxy-1 -methoxy ethane, 1,1-diethoxyethane, 2,2-diethoxypropane, n-butylacetate... 

To a mixture of 50 g 2-[4-[(4-chlorophenyl)phenylmethyl]-l-piperazinyl]-ethanol and 225 ml of tert-butanol at 45°C under a nitrogen was added 21 g tert-BuOK. The temperature was raised to 75-80°C and the mixture was kept at this temperature. After 45 min was added 11 g sodium chloracetate after 1.5 hour was added 5.2 g tert-BuOK after 2 hours was added 5.64 g sodium chloracetate after 2.5 hours was added 1.9 g tert-BuOK after 3 hours was added 1.9 g sodium chloracetate after 3.5 hours was added 0.8 g tert-BuOK and after 4 hours was added 1.13 g sodium chloracetate. Then about 150 ml tert-butanol was distilled of, 190 ml of water was added and the distillation of tert-butanol was continued until the temperature of the vapour reaches 100°C. To the reaction mixture was added 60 ml of water and 8 ml concentrated hydrochloric acid to pH 8. Unreacted 2-[4-[(4-chlorophenyl) phenylmethyl]-l-piperazinyl]-ethanol was extracted with diethyl ether. The aqueous phase was acidified to pH 5 by addition of hydrochloric acid and extracted with dichloromethane (200 ml x 3). The extract was dried over MgS04, filtered and concentrated in a rotary evaporator. An obtained oil was allowed to crystallize by addition of 150 ml of 2-butanone, yields of 2-[4-[(4-chlorophenyl)phenylmethyl]-l-piperazinyl]-ethoxy]acetic acid 55.5%, M.P. 146-148°C. 

The same system was employed in the reduction of 4-phenyl-2-butanone to (S)-4-phenyl-2-butanol using HLADH as well as 5-ADH from Rhodococcus sp. with high enantioselectivity [113]. With pentamethylcyclopentadienyl-4-ethoxy-methyl-2,2 -bipyridinechloro-rhodium(III) as mediator and HLADH as catalyst, after 5 h 70% of 4-phenyl-2-butanone was reduced to (S)-4-phenyl-2-butanol with 65% ee. Using 5-ADH. 76% of the ketone was converted to the (S)-alcohol after 5 h with 77% ee. Furthermore, this system has been applied in an electrochemical EMR with a polymer bound rhodium complex as mediator. 

As stated previously, the alkaline degradation of polysaccharides proceeds by a peeling process in which the reducing end-group is liberated from a chain by elimination of the rest of the chain asa glycoxyanion. Elimination takes place when the chain is in the position beta to a carbonyl group of the reducing end-unit. Eliminations of this type can be exemplified by the action of alkali on 4-ethoxy-2-butanone (IV) to form 3-buten-2-one (V). 

Methoxybenzyl acetate p-M ethoxy benzyl acetate. See p-Anisyl acetate 4-Methoxybenzylacetone. See 4-p-Methoxyphenyl-2-butanone 2-Methoxybenzyl alcohol. See o-Anisyl alcohol 4-Methoxybenzyl alcohol. See p-Anisyl alcohol 4-Methoxybenzyl alcohol (o-, m-, p-). See Anisyl alcohol... 

Amino-3-methyl-2-ethoxy-2-oxo-l,2-oxaphospholane can be prepared in a similar fashion by aminophosphonylation of 4-benzoyloxy-2-butanone, followed by reduction of the first intermediate over palladium catalyst and cyclization of the second intermediate using catalytic amounts of base. 

Ligustrum also contains a unique volatile oil consisting primarily of esters and alcohols, with lesser amounts of thioketones, hydrocarbons, and traces of amines and aldehydes, but no terpene hydrocarbons. Major components of the volatile oil include ethyl acetate (18.95%), thioketone (8.56%), a-butyl-benze-nemethanol (5.6%), 4-acetyloxy-2-butanone (5.46%), 1-phenyl-1,2-butanediol (4.12%), 1,2-diphenyl-l,2-ethanediol (3.92%), hydra-zine-methyl-oxalate (3.52%), a,a,4-tri-methyl-3-cyclohexene-methanol (3.24%), 1-methyl-l-propyl-hydrazine (2.60%), and (Z)-1 -(1 -ethoxy-ethoxy)-3-hexene (1.89%). ... 

C12-C16 alkyl 3- to 14-mole ethoxy- Silica Gel 60 F254 2-Butanone, saturated with H2O Modified Dragendorff reagent 96... 

C 3-C,8 alkyl 3- to 11-mole ethoxylates ethoxy distribution Silica Gel 60 or Silica Gel 60 F-254, 0.25 mm 2-Butanone or 90 10 EtOH/HOAc or 80 20 BuOH/EtOH or 60 10 20 0.5 BuOH/EtOH/H20/ HOAc Acid Blue 158 49... 

Fatty acid monoethanolamide ethylene oxide adducts ethoxy distribution Silica Gel G, activated at 1 lO C 2-Butanone, H20-saturated Iodine vapor or modified Dragendorff reagent 58... 

Fatty acid 8-mole ethoxylates ethoxy distribution Merck Silica Gel G, activated at 120 Cfor30min 2-Butanone, saturated with water Modified Dragendorff reagent 41... 

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