Acetic ethoxy

Acetals or ketals, like simple ethers, participate in many displacement reactions. Although a smaller amount of data is available upon which to draw conclusions about the facility of the acetal participation, the results seem comparable to those of simple ethers. For example, 4-chloro-l,l-diethoxybutane (137) is said to liberate chloride ion in the presence of potassium hydroxide much faster than 5-chloro-l,l-diethoxypentane. The rate difference was attributed to participation by the acetal ethoxy... 

Alkynes with EWGs are poor substrates for the coupling with halides. Therefore, instead of the inactive propynoate, triethyl orthopropynoate (350) is used for the coupling with aryl halides to prepare the arylpropynoate 351. The coupling product 353 of 3,3-dicthoxy-l-propyne (352) with an aryl halide is the precursor of an alkynal[260]. The coupling of ethoxy) tributylstan-nyl)acetylene (354) with aryl halides is a good synthetic method for the aryl-acetate 355[261]. 

NBS, CH3CN, H2O, 62-90% yield.The POM group has been selectively removed in the presence of an ethoxy ethyl ether, TBDMS ether, benzyl ether, p-methoxybenzyl ether, an acetate, and an allyl ether. Because the hydrolysis of a pentenyl 2-acetoxyglycoside was so much slower than a pentenyl 2-benzyloxyglycoside, the 2-benzyl derivative could be cleaved selectively in the presence of the 2-acetoxy derivative. The POM group is stable to 75% AcOH, but is cleaved by 5% HCl. 

Ethoxy-7V,7V-diethylaniline [1846-92-2] M 193.3, b 141-142 /15mm pK st 6-l- Refluxed for 3h with acetic anhydride, then fractionally distilled under reduced pressure. 

The hydrolysis of 3-ethoxy-4-ethylbicyclo[4.1.0]hept-4-en-7-one propylene acetal (1) with aqueous acetic acid in tetrahydrofiiran gives an oil with the molecular formula CnH/gOi, from which the INADEQUATE contour plot 22 and DEPT spectra were obtained. What is the compound ... 

Hydroxy-20-ketones via Ethoxyethynyl Carbinols A solution of 3, 17/ -dihydroxy-21-ethoxy-17a-pregn-5-en-20-yne 3-acetate (5 g) in ethanethiol (10 g) to which di-t-butyl peroxide (0.95 g) has been added is refluxed for 4 hr... 

Ethoxyacetylene, 74, 136, 138, 181 1 -Ethoxycyclohepta-1,3,5-triene, 365 1-Ethoxycyclohexene, 365 1 - Ethoxy-7,7-dichloronorcarane, 365 17a-Ethoxyethynylandrost-5-ene-3, 17 -diol 3-acetate, 181, 182 Ethoxyethynylmagnesium bromide, 138 21 -Ethoxy-3-methoxy-19-norpregna-1,3,5(10) -trien-20-yne-17 -oI, 139 Ethyl 3 -acetoxy-17/3-hydroxy-17 a-pregn-5-en-21-oate, 139... 

FluorO-11/3-hydrOxy-16/3-methyl-170 .21-(r-ethyl-1 -ethoxy methylenedioxyipreg-na-1,4-dlene-3.20-dione Acetic Acid Propionyl Chloride... 

Chamical Name 4-[2-(Dimethvlamino)ethoxy] 2-methyl-5-(1-methylethyD-phenol acetate (ester)... 

Ethyl 5-(p-chlorobenzoyl)-1,4-dimethyl-3-ethoxy pyrrole-2-acetate Zomepirac... 

The synthesis of the right-wing sector, compound 4, commences with the prochiral diol 26 (see Scheme 4). The latter substance is known and can be conveniently prepared in two steps from diethyl malonate via C-allylation, followed by reduction of the two ethoxy-carbonyl functions. Exposure of 26 to benzaldehyde and a catalytic amount of camphorsulfonic acid (CSA) under dehydrating conditions accomplishes the simultaneous protection of both hydroxyl groups in the form of a benzylidene acetal (see intermediate 32, Scheme 4). Interestingly, when benzylidene acetal 32 is treated with lithium aluminum hydride and aluminum trichloride (1 4) in ether at 25 °C, a Lewis acid induced reduction takes place to give... 

Amino-77/-dibenz[/),t/]azepin-7-ones, e.g. 7, prepared either by successive bromination, aminodebromination, and dehydrogenation of 5-tosyl-5A/-dihydro 7>,t/]azepin-7(6//)-ones, or by the oxidation of 6-ethoxy-6,7-dihydro-5//-dibenz 7>,r/]azepincs with lead(IV) acetate followed by aminodemethoxylation, on treatment with a bidentate nucleophile (e.g.. benzene-1,2-diamine or 2-aminobenzenethiol) yield the pentacyclic systems 8 and 9, respectively.27... 

A solution of 4.5 g (19.9 mmol) 4-(fm-butyldimethylsilyloxy)-2-cyclohexenone and 452 mg (1 mmol) of mercury(II) iodide is stirred at r.t. for 15 min and then cooled to — 78 °C. 5.03 g (24.8 mmol) of 1-ethoxy-1-(tm-bulyl(iimethylsilyloxy)ethene are added dropwise during 15 min. The mixture is stirred at — 78 °C for 2 h, quenched with 302 mg (3 mmol) of triethylamine and allowed to warm to r.t. The mixture is filtered through a short (3 cm) column of silica gel (deactivated with a 5% triethylamine solution in hexane/ethyl acetate, 10 1) eluting with hexane/ethyl acetate (10 1) and concentrated in vacuo. Purification of the crude material by flash chromatography (silica gel, hcxanc/cthyl acetate 30 1) gave the adduct as a colorless oil yield 7.98 g (18.7 mmol, 94%) d.r. (cisjtrans) 95.2 4.8. 

A solution of the trimethylsilyl enol ether of propionyl trimethylsilane (5 mmol) (Chapter 12) and benzaldehyde diethyl acetal (5 mmol) in dichloromethane (10ml) was added to a solution of BF3.OEt2 (5 mmol) in dichloromethane (5ml), cooled to —78 C. After being stirred for lh at -78°C and 2h at -30°C, the mixture was quenched with excess saturated sodium hydrogen carbonate solution, and extracted with ether. Concentration and distillation gave the product -ethoxy acylsilane, (4.6mmol, 95%). b.p. 105-106 C/2mmHg. Treatment of this alkoxy... 

Acetic acid, nitro-, methyl ester, 55, 77, 78 Acetic acid, trifluoro-, 55 70 Acetonitrile, diphenyl-, 55, 94, 102 Acetonitrile, diphenyl-2-(l-ethoxyethenyl)-[ Acetonitrile, diphenyl-2-(l-ethoxy-vinyl)-, 55, 102... 

CN ( )-[2-[4-[(4-chlorophenyI)phenylmethyI]-l-piperazinyI]ethoxy]acetic acid... 

CN 4-[2-(dimethylamino)ethoxy]-2-raethyl-5-(l-methylethyl)phenol acetate (ester) hydrochloride... 

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