Ethoxy acetic acid

CN ( )-[2-[4-[(4-chlorophenyI)phenylmethyI]-l-piperazinyI]ethoxy]acetic acid... 

After treatment of XXXVI with aqueous barium hydroxide, the liquor contained formic, methoxyacetic, and ethoxyacetic acids, methoxyacetone, and ethoxyacetone, produced by the two modes of cleavage XXXVIa and XXXVIb. Formic acid was converted with red mercuric oxide to carbon dioxide this was recovered as barium carbonate, the radioactivity of which was a measure of the C14 incorporated into Cl of kojic acid in the biosynthetic process. The alkoxyacetones were removed from the liquor by steam distillation, and converted to iodoform and a mixture of methoxy- and ethoxy-acetic acids. The iodoform was recovered by filtration its radioactivity indicated the proportion of C14 incorporated into C4. The alkoxy-... 

Ethoxyacetamide (Athoxyacetamid or Athyl-atherglykolsaureamid, in Ger), C2H5O.CH.2CONH2 mw 103.12, N 13-58% plates (from benz) mp 82.5°(sublimes), bp 225° at 75mm Hg easily sol in w, ale, eth, benz and CS2. It can be prepd by action of aqueous ammonia on ethyl ester of ethoxy-acetic acid or by action of ammonia on acetoxy-acetyl chloride in ether... 

To a mixture of 50 g 2-[4-[(4-chlorophenyl)phenylmethyl]-l-piperazinyl]-ethanol and 225 ml of tert-butanol at 45°C under a nitrogen was added 21 g tert-BuOK. The temperature was raised to 75-80°C and the mixture was kept at this temperature. After 45 min was added 11 g sodium chloracetate after 1.5 hour was added 5.2 g tert-BuOK after 2 hours was added 5.64 g sodium chloracetate after 2.5 hours was added 1.9 g tert-BuOK after 3 hours was added 1.9 g sodium chloracetate after 3.5 hours was added 0.8 g tert-BuOK and after 4 hours was added 1.13 g sodium chloracetate. Then about 150 ml tert-butanol was distilled of, 190 ml of water was added and the distillation of tert-butanol was continued until the temperature of the vapour reaches 100°C. To the reaction mixture was added 60 ml of water and 8 ml concentrated hydrochloric acid to pH 8. Unreacted 2-[4-[(4-chlorophenyl) phenylmethyl]-l-piperazinyl]-ethanol was extracted with diethyl ether. The aqueous phase was acidified to pH 5 by addition of hydrochloric acid and extracted with dichloromethane (200 ml x 3). The extract was dried over MgS04, filtered and concentrated in a rotary evaporator. An obtained oil was allowed to crystallize by addition of 150 ml of 2-butanone, yields of 2-[4-[(4-chlorophenyl)phenylmethyl]-l-piperazinyl]-ethoxy]acetic acid 55.5%, M.P. 146-148°C. 

To the suspension of 2-[(2-phthalimido)ethoxy] acetic acid (0.4 mol) in 1.0 L toluene and 1ml dimethylformamide was added thionyl chloride (1.46 mol) at ambient temperature and the mixture heated to 60°C 3 hours. The reaction mixture was concentrated under reduced pressure and the product isolated. 

The acyclo C-nucleoside 811 was prepared in a closely similar plan to that used for the synthesis of its cyclic analog 808. [2-(Benzoyloxy)ethoxy]-acetic acid was condensed with 6-aminomethyl-l,2,4-triazin-5-one to give amide 810, which was then cyclized and de-C>-benzoylated to 811. This truncated sugar acyclo C-nucleoside did not inhibit herpes simplex viruses (HSV-1 and HSV-2) in cell culture (84JHC697) (Scheme 213). 

Coupling of [2-(benzoyloxy)ethoxy]acetic acid (809) or [2-(l,3-diben-zoyloxy)propoxy]acetic acid 829 with 3-amino-6-hydrazino-l,2,4-triazin-5-one gave the two amides 827 and 830, respeetively. Thermal cyclodehydration of 827 and 830 and subsequent deprotection gave the two truncated-sugar acyclo C-nucleosides 828 (84JHC697) and 831 (95MI6) (Scheme 217). 

Amides of various types can be obtained by the simple mixing of carboxylic acids and amines with DEPC in the presence of NEt3. Amide 25 is prepared from l-phenyl-2-piperidinylethylamine (24) and methoxy ethoxy acetic acid (23) using DEPC in 90% yield.10... 

Buten-2-one, 3-methyl-4-phenyl-. See 3-Methyl-4-phenyl-3-buten-2-one 3-Buten-2-one, 3-methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-. See a-lsomethylionone 3-Buten-2-one, 4-(2,4,6,6-tetramethyl-2-cyclohexen-1-yl)-. Seea-lrone (2-Butenylidene) acetic acid. See Sorbic acid Butesin. See Butyl PABA Buteth-2 carboxylic acid CAS 75427-76-8 107600-34-0 Synonyms Acetic acid, [2-[2-butoxyethoxy] ethoxy]- [2-[2-Butoxyethoxy] ethoxy] acetic acid PEG-2 butyl ether carboxylic acid PEG 100 butyl ether carboxylic acid POE (2) butyl ether carboxylic acid Classification Organic acid Empirical C10H20O5... 

Butoxyethanol phthalate (2 1). See Dibutoxyethyl phthalate Butoxyethene. See n-Butyl vinyl ether 2-(2-Butoxyethoxy) ethanol. See Butoxydiglycol 2-(2-Butoxyethoxy) ethanol acetate. See Diethylene glycol butyl ether acetate [2-[2-Butoxyethoxy] ethoxy] acetic acid. See Buteth-2 carboxylic acid 2-(2-(2-Butoxyethoxy) ethoxy) ethanol. See Butoxytriglycol... 

Fig. 3 Chemical stracture of 2-[2-[2-[(2-bromoacetyl)amino] ethoxy] ethoxy] ethoxy acetic acid (3) used to introduce the acetyl bromo functionality to DPPE, as described by Frisch et al. [42]...

R)-(4-chlorophenyl) (phenyl)methyl] piperazin-l-yl ethoxy)acetic acid (Levocetirizine - Xyzal) Antihystaminic ... 

The rates increase with increasing dielectric constant, and H20+Br is the reactive oxidant species. The oxidation of [2-(2- 4-[(4-chlorophenyl)(phenyl)methyl]-l-piperazino ethoxy) acetic acid dihydrochloride (CTZ) by BAT in HCl has a negative fractional dependence in H+ ion, and the rates decrease with increasing dielectric constant of the solvent. CH3C6H5S02NHBr is the reactive BAT species. " The oxidation of cetrizine dihydrochloride (CTZH) with BAT has been investigated both in acid and alkaline medium. A negative fractional order in H+ ion and positive fractional order in HO ion are reported, accompanied by a fractional order in CTZH in both acidic and alkaline media. The rate increases with increasing dielectric constant of the solvent. The reaction in alkaline medium has fractional order in p-toluenesulfonamide (PTS). The oxidation rate of CTZH is faster in acid medium and 4-chlorobenzophenone and (2-piperazine-l-yl-ethoxy)-acetic acid are the oxidation products. ... 

---