Ethanol Ether

LiS03p [13453-75-3] white powder 360 V s V s ethanol, ether, acetone, amyl alcohol, ethyl acetate i ligroin... 

Allylestrenol. Allylestrenol (37), which has been used to treat cases of habitual abortion (55), can be recrystaUized from ether/petroleum ether (56). It is soluble in acetone, ethanol, ether, and chloroform and practically insoluble in water (57). The uv and ir spectra have been reported (58). AHylestrenol is sensitive to oxidising agents (57). 

LynestrenoL Lynestrenol (73) has been used in oral contraceptives and to treat menstrual disorders. It is converted in vivo to its active metabohte norethindrone (102,103). It can be recrystallized from methanol, and is soluble in ethanol, ether, chloroform, and acetone, and insoluble in water (102). The crystal stmcture (104) and other spectral and analytical data have been reported for lynestrenol (62). 

Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water. They can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides. 

Crystd from water or ethanol/ether. POISONOUS. 

The resultant mixture is evaporated in vacuo and the residue triturated with methylene chloride to afford a crude product. Recrystallization from ethanol-ether (1 3) provides 1 -(2.6-di-chlorobenzylideneamino)-3-hydroxyguanidine hydrochloride MP 173°C to 175°C. When the above process is carried out and S-benzylisothiosemicarbazide hydroiodide is used in place of S-methylisothiosamicarbazide hydroiodide, the identical product is again obtained. 

After cooling, unreacted ethylenediamine is neutralized in a cooling mixture with the absolute ethanolic hydrochloric acid, filtered off from any components that are insoluble in ethanol and approximately two-thirds of the solvent filtered off under suction in a water jet pump vacuum. Residual quantities of ethylenediamine dihydrochloride are precipitated in fractions by the careful addition of ethyl methyl ketone, after which the imidazoline hydrochloride is separated off by the addition of dry ether. Following repeated recrystallization from ethanol ether, 2-[0(-(2,6-dichlorophenoxy)ethyl] -A -imidazoline hydrochloride is obtained in the form of small white crystals melting at 221°C to 223°C. 

A solution or dispersion consisting of 20.1 g (0.1 mol) of 7-chloro-p-fluorobutyrophenone, 19.8 g (0.2 mol) of 4-methylpiperidine end 0.1 g of potassium iodide in 150 ml toluene is heated in a seeled gless tube for 15 hours at 100°C to 110°C. The potassium iodide and the 4-methylpiperidine hydrochloride formed in the reaction are separated by filtration and the solvent removed from the filtrate by evaporation In vacuum on a steam bath. The residue is distilled and the fraction obtained at 120°C to 125 0 and at a pressure lower than 0.1 mm Hg is collected. The basa Is dissolved in ether and the 4-fluoro-7-(4-methylpiperidino)-butyro-phenone precipitated as the hydrochloride. The reaction product is purified by recrystallization in ethanol/ether. 

The product obtained by evaporation of the eluate was recrystallized from ethanol-ether (1 10) to give a light yellow powder, MP 85°C to 88°C. The yield was 44 g (63%). 

To a solution of 0.05 mol of the above-obtained ester in about 100 ml of anhydrous benzene there are added 15 ml of methyl iodide. The ensuing mixture is refluxed for several hours whereupon the quaternary salt is deposited and removed by filtration. Recrystallization from ethanol or ethanol-ether yields the quaternary salt, melting point 199°C to 200°C. 

The hydrochloride salt of this amine was prepared by dissolving the amine in ether and adding ethereal hydrogen chloride to the ether solution. The solid hydrochloride salt which precipitated was racrystallized from an ethanol-ether mixture and was found to melt at 154°-155°C. 

CH3)2. CH.CH2.CH3 mw 72.15, colorl liq, mp -159.9°, bp 27.85°, d 0.6201 g/cc at 20/4°, RI 1.35370. Sol in ethanol, ether, hydrocarbons and oils, insol in w. First prepd by Frankland in 1850 by treating iso-amyl iodide with Zn in w at 140° (Ref 2). It was isolated by Young from American petroleum (Ref 3). Present methods of prepn include fractional distn of petroleum and subsequent purification of the crude isopentane by rectification, as well as cracking and reforming of crude oil components and natural gasolines in oil refineries (Refs 4 7)... 

Figure 4. Absorption and emission of TIN and MT in different solvents (I) absorption of TIN in methylcyclohexane/isopentane at 150 K (II) absorption of TIN in ethanol/methanol at 150 K (III) absorption of MT in hexane at 296 K (IV) (a) fluorescence and (b) phosphorescence of TIN or MT in 20 20 1 ethanol/ether/pyridine at 90 K (V) fluorescence of TIN in methylcyclohexane/isopentane at 90 K.

A very powerful oxidant uncontrolled contact with aniline, benzene, ethanol, ether, nitrobenzene or phenol may cause explosion [1], Alkanes are slowly carbonised [2],... 

Kojic acid is readily soluble in water, ethanol, and acetone sparingly soluble in ether, ethyl acetate, chloroform, and pyridine and difficultly soluble in most other liquids.4-T It has been purified by recrystallization from acetone,7 ethanol-ether,20 and methanol-ethyl acetate26 also, by sublimation under diminished pressure at8-26-64 150-200°C. The m. p. (in °C.) has been given as 151-152,20-42 152,3-21-64 152.6,37 152-153,43 153-154,29 -31 and 154.6-6 The molecular weight was determined by the cryo-scopic method,4- 7-31 and the values obtained agreed well with the calculated value of 142. 

Solubility of Pseudoephedrine Hydrochloride at 25°C Solvent Water Chloroform Ethanol Ether... 

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