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Estrogen receptor a

Sex steroid receptors are members of the steroid hormone receptor (SHR) family that ligand-dependently regulate functions of the sexual organs. Sex steroid receptors are the androgen receptor [1] (AR), the estrogen receptor a [2] and (3 [3] (ERa, ER 3), and the progesterone receptor [4] (PR). [Pg.1126]

IA (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors a and (3. Endocrinol. 138, 863-70. [Pg.103]

This chapter reviews the main characteristics of two of the better known members of the nuclear hormone receptor family estrogen receptors a and ft (ERa and ER/i). First, the different functional regions harbored by the molecule of the receptor are described. These properties will be used to describe the cellular, molecular, and other consequences that derive from the interactions of receptors with their own hormone, other proteins, or DNA. [Pg.19]

Table 1.1. Relative binding affinity of ligands to estrogen receptors a and/3... Table 1.1. Relative binding affinity of ligands to estrogen receptors a and/3...
Table 1.2. Principal effects of knocking out genes for estrogen receptors a and ft in the mouse... [Pg.53]

Azuma K, Horie K, Inoue S, Ouchi Y, Sakai R (2004) Analysis of estrogen receptor a signalling complex at the plasma membrane. FEBS Lett 577 339-344... [Pg.139]

Herbison AE, Skynner MJ, Sim JA (2001) Lack of detection of estrogen receptor-a transcripts in mouse gonadotropin-relesing hormone neurons. Endocrinology... [Pg.143]

Hiroi H, Inoue S, Watanabe T, Goto W, Orimo A, Momoeda M, Tsutsumi O, Taketani Y, Muramatsu M (1999) Differential immunolocalization of estrogen receptor a and (S in rat ovary and uterus. J Mol Endocrinol 22 34-44... [Pg.143]

Mitchner NA, Garlick C, Ben-Jonathan N (1998) Cellular distribution and gene regulation of estrogen receptors a and f) in the rat pituitary gland. Endocrinology 139 976-3983... [Pg.146]

Nishihara E, Nagayama Y, Inoue S, Hiroi H, Muramatsu M, Yamashita S, Koji T (2000) Ontogenic changes in the expression of estrogen receptor a and p in rat pituitary gland detected by immunohistochemistry. Endocrinology 141 615-620... [Pg.146]

Schreihofer DA, Rowe DF, Rissman EF, Scordalakes EM, Gustaffsson JA, Shupnik MA (2002) Estrogen receptor-a (ERa), but not ER/J, modulates estrogen stimulation of the ERa-truncated variant, TERP-1. Endocrinology 143 4196-4202... [Pg.148]

Scully KM, Gleiberman AS, Lindzey J, Lubhan DB, Korach KS, Rosenfeld MG (1997) Role of estrogen receptor-a in the anterior pituitary gland. Mol Endocrinol 11 674-681... [Pg.149]

Skynner MJ, Sim JA, Herbison AE (1999) Detection of estrogen receptor a and ft messenger ribonucleic acid in adult gonadotropin-releasing hormone neurons. Endocrinology 140 5195-5201... [Pg.149]

Wersinger SR, Haisenleder DJ, Lubahn DB, Rissman EF (1999) Steroid feedback on gonadotropin release and pituitary gonadotropin subunit mRNA in mice lacking a functional estrogen receptor a. Endocrine 11 137-143... [Pg.151]

Gorodeski GI and Pal D [2000] Involvement of estrogen receptors a and p in the regulation of cervical permeability. Am J Physiol 278 C689-C696... [Pg.359]

The use of structure-based virtual screening toward novel nuclear hormone receptor antagonists was described by Schapira et al. [263]. As only X-ray structures of ligand binding domains of agonist-bound nuclear receptors with exception of the antagonist-bound estrogen receptor-a are available, the authors constructed an inactive ... [Pg.93]

Del Rio B, Pedrero JMG, Martinez-Gampa G, ZuazuaP, Lazo PS, Ramos S, Melatonin, an endogenous-specific inhibitor of estrogen receptor a via calmodidin, J Biol Chem 279 38294-38302, 2004. [Pg.470]

TAS-108 (SR16234) is a novel and orally active steroidal compound with a proposed additional molecular mode-of-action that is different from that of SERMs such as tamoxifen and raloxifene [157]. TAS-108 is a full estrogen receptor-a antagonist, and it should also recruit co-activator transcriptional intermediary factor 2 to ER-j6, which may have a preventive effect on bone loss [157]. [Pg.55]

The possible role of isoflavonoids in the prevention of cancer and in particular hormone-dependent cancers such as breast and prostate cancer is currently extensively investi-gated. " " In addition, consumption of soy foods rich in isoflavones has been weakly associated with reduced colon cancer. Colon cancer risk is influenced by estrogen exposure although the mechanism of action has not been fully elucidated, studies with estrogen receptor a (see Section 7.3.3) knockout mice indicate that it may be independent of estrogen receptor... [Pg.377]

Saji S, Jensen EV, Nilsson S, Rylander T, Warner M, Gustafsson J-A. Estrogen receptors a and (i in the rodent mammary gland. Proc. Natl Acad. Scl USA 97, 337-342, 2000. [Pg.391]

Arts J, Kuiper GGJM, Janssen, JMMF et al. Differential expression of estrogen receptors a and (3 mRNA during differentiation of human osteoblast SV-HFO cells. Endocrinology 138, 5067-5070,... [Pg.391]

Makela S, Savolainen H, Aavik E et al. Differentiation between vasculoprotective and uterotropic effects of ligands with different binding affinities to estrogen receptors a and (3. Proc. Natl. Acad. Scl USA 96, 7077-7082, 1999. [Pg.391]

See other pages where Estrogen receptor a is mentioned: [Pg.234]    [Pg.388]    [Pg.389]    [Pg.414]    [Pg.414]    [Pg.102]    [Pg.144]    [Pg.147]    [Pg.148]    [Pg.149]    [Pg.317]    [Pg.414]    [Pg.309]    [Pg.338]    [Pg.339]    [Pg.351]    [Pg.355]    [Pg.368]    [Pg.56]    [Pg.728]    [Pg.244]    [Pg.124]    [Pg.124]    [Pg.20]    [Pg.445]    [Pg.516]   
See also in sourсe #XX -- [ Pg.121 , Pg.242 ]

See also in sourсe #XX -- [ Pg.249 ]

See also in sourсe #XX -- [ Pg.326 ]



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