Equipment cleaning maintenance

A written record of major equipment cleaning, maintenance (except routine... 

A written record of major equipment cleaning, maintenance (except routine maintenance such as lubrication and adjustments), and use shall be included in individual equipment logs that show the date, time, product, and lot number of each batch processed. 

Major/critical equipment cleaning, maintenance, and use Master production control and batch records... 

Failure to have a written individual record of major equipment cleaning, maintenance, and usage [21 CFR 211.182], There were no equipment logs for the bar code scanner, programmed label reviewer, and the roll splicing equipment. ... 

Process operations. The third source of process waste we can classify under the general category of process operations. Operations such as start-up and shutdown of continuous processes, product changeover, equipment cleaning for maintenance, tank filling, etc. all produce waste. 

Existing maintenance procedures must be reviewed for several reasons. Typically, these are established based upon manufacturers recommended practices for stock equipment such as pumps, centrifuges and some reactors. However, a new toll can introduce special cleaning and preparation steps as well as possible material of construction incompatibilities. If the toller is using new equipment, special maintenance practices and tools may also be required. 

Tolling presents a special consideration that can make the training step easier. Typically a toller s technical staff, operators and mechanics are knowledgeable in the basic operations and tasks related to the toller s specialty. For example, experienced operators may know operations of the reactors, columns, exchangers, and packaging equipment quite well. The mechanical personnel may be very familiar with the required safe work practices, equipment cleaning procedures and maintenance tasks for standard vessels and piping. 

This chapter deals with the essential factors in the selection of systems and equipment during the design stage principles of controls, noise-reduction systems, and problems such as erosion, corrosion, maintenance and equipment cleaning, etc. 

No plant will operate continuously without shut-down. Planned shut-down periods will be necessary for maintenance, inspection, equipment cleaning, and the renewal of catalysts... 

General maintenance tasks, including adjustment of flow meters and measuring equipment, cleaning ponds, mowing grass and winter service (some of which are outsourced). 

All aspects of a laboratory s program for the routine inspection, cleaning, maintenance, testing, calibration, and/or standardization of equipment must be in writing (i.e., SOPs, supplemented as necessary by equipment manuals). This would include a description of cleaning materials inspection, cleaning, and maintenance methods and schedules calibra-... 

Access to the critical parts of the equipment for maintenance and cleaning should be available. 

Equipment cleaning SOPs/equipment sanitization SOPs Preventive maintenance SOPs Calibration SOPs Training SOPs... 

Verify that employees involved for equipment operation, maintenance, calibration, and cleaning have received adequate training. 

Facility and equipment design Equipment maintenance Equipment cleaning Calibration Materials control... 

Significantly more water is used in supporting operations, such as generation of WFI, equipment cleaning and sterilization, wastes processing, and facility maintenance. 

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