Environmental mutagenesis

Zeiger E, Anderson B, Haworth S, et al. 1987. Salmonella mutagenicity tests III. Results from the testing of 255 chemicals. Environmental Mutagenesis 9 1-18. 

Probst GS, McMahon RE, Hill LE, et al. 1981. Chemically-induced unscheduled DNA synthesis in primary rat hepatocyte cultures A comparison with bacterial mutagenicity using 218 compounds. Environmental Mutagenesis 3 11-32. 

Zeiger E, Haworth S, Speck W, et al. 1982. Phthalate ester testing in the National Toxicology Program s environmental mutagenesis test development program. Environ Health Perspect 45 99-101. 

Blackburn G, Deitch R, Schreiner C, et al. 1987. Testing of petroleum middle distillates in a modified Ames assay. Environmental Mutagenesis 9 15. 

Ashby, J. (1985) Fundamental structural alerts to potential carcinogenicity or non-carcinogenicity. Environmental Mutagenesis, 7, 919—921. 

Table 5.Z—Potentially important metaboUc reactions that may play a role in environmental mutagenesis and carcinogenesis...

Schairer, L.A. Sautkulis, R.C. (1982) Detection of ambient levels of mutagenic atmospheric pollutants with the higher plant Tradescantia. In Klekowski, E.J., ed.. Environmental Mutagenesis, Carcinogenesis and Plant Biology, Vol. 2, New York, Praeger, pp. 154-194... 

It was the consensus of the panel participants that the methods summarized here represent the best available technology to prepare environmental samples for the Ames assay. These methods were chosen, after group discussion, on the basis of the collective laboratory experience of the participants and a thorough review of the literature. However, these are interim protocols subject to laboratory validation. This validation effort has been initiated, and workers in the field of environmental mutagenesis are urged to test these interim protocols in their own laboratories. 

Radman, M., Wagner, B.W., Glickman, B.W., Meselson, M. (1980). DNA methylation, mismatch correction and genetic stability. In Progress in Environmental Mutagenesis (Alacevic, M., Ed.), pp. 121-130. Elsevier/Nth. Holland Biomedical, Amsterdam. 

DiLemia R, Crimaudo C, Pacchetti G. 1982. The study of X-rays and TCDD effects on satellite associations may suggest a simple model for application in environmental mutagenesis. Hum Genet 61 42-47. 

Zeiger E. 1983. Memorandum from Dr. Zeiger to Dr. E.E. McConnell on the results of test performed for the Environmental Mutagenesis Development Program. NTP, NIEHS. 

The Commission has an international membership drawn from universities, research institutions, industry, and national health organizations. Its objectives are "to identify and promote scientific principles in the fields of environmental mutagenesis, carcinogenesis, and genetic toxicology"182 256 and "to prevent and minimize the deleterious effects resulting from the interaction of chemicals with the genetic material of man." 25 To pursue these objectives,... 

TABLE 4-1 Metabolic Reactions That May Be Important in Environmental Mutagenesis... 

Besides serving as in situ monitoring systems, plants are potentially valuable in environmental mutagenesis, because they can metabolically activate some compounds. 

Sutton, H.E. Prospects of monitoring environmental mutagenesis through somatic mutations, pp. 237-248. 

Geneticists Early Resistance to the Environmental Mutagenesis Thesis... 

In cases where individuals listed several research interests, I chose those two or three that seemed most closely related to environmental mutagenesis. 2Attended first EMS meeting in Washington, D.C., February 8,1969. 

The retrospective attention that insiders have lavished upon Chemical Risk, as well as the shot heard around the world impact the article had at the time of its publication, is somewhat paradoxical. Chemical Risk was not the first article to address the issues it raised, nor was the knowledge it imparted unfamiliar territory, especially for those working in mutation research. Nevertheless, the article struck a highly responsive chord among many in mutation research and beyond. Its publication on the eve of scientists mobilization around the issue of environmental mutagenesis suggests that the ideas and concerns expressed in Chemical Risk —and perhaps even more important, the manner in which those ideas were packaged—played an unexpectedly important role. 

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