Environmental control, microbial

The degree of environmental control of particulate and microbial contamination of the production premises should be adapted to the product and the production step, bearing in mind the level of contamination of the starting materials and the risk to the finished product. 

Microbial environmental control data 8. Acceptance Criteria... 

The major source of microbial contamination of controlled environments is personnel. Since the major threat of contamination of product being aseptically processed comes from the operating personnel, the control of microbial contamination associated with these personnel is one of the most important elements of the environmental control program. Personnel training should be conducted before the qualification and validation practice [13]. 

Chrdst, R. J. (1991). Environmental control of the synthesis and activity of aquatic microbial ectoenzymes, In Microbial Enzymes in Aquatic Environments, Chrdst, R. J., ed., Springer-Verlag, New York, pp. 29-59. 

An area (or room) with defined environmental control of particulate and microbial contamination, constructed and used in such a way as to reduce the introduction, generation and retention of contaminants within the area. commissioning... 

A considerable amount of research effort has been expended for the management of spray drift in Europe and North America. However, not only has exodrift been reduced at the expense of endodrift (as discussed above), but conventional drift control may also impose substantial burdens on the development of environmentally benign microbial agents. Since effective delivery... 

Environmental Controls in Production. Environmental permit requirements should be evaluated based on the commercial-scale material balance and new equipment specifications. Testing requirements for environmental evaluation should include acute fish and invertebrate toxicity for raw materials, intermediates, and products biodegradation of raw materials, intermediates, and products microbial growth inhibition of raw materials, intermediates, and products water coefficients (KOW) and water solubility for raw materials, intermediates, and products and waste treatability test results. Particular emphasis should be placed on the evaluation of the compatibility of the new process waste streams with the existing waste-treatment systems. If any process waste streams require off-site disposal into regulated hazardous waste landfills, leaching experiments may also be required. 

Kerry BR, Jaffee BA. Fungi as biological control agents for plant-parasitic nematodes. In Wicklow DT, Soderstrom B, eds. The Mycota IV. Environmental and Microbial Relationships. Berlin Springer-Verlag, 1997, pp 201-218. 

Stabilisation by climate control. The most desirable method to prevent damage induced by the repeated cycles of crystallisation and hydration would probably be environmental control. However, neither the selection nor the maintenance of such an ideal environment is possible if looked at realistically. Predictions of salt crystallisation and hydration from mixed salt solutions are more or less impossible, taking into account all the different parameters that influence the process. Sawdy provides a brilliant overview of the subject and considers relative humidity, temperature, air movement, type and structure of the porous support, salt mixture composition and salt concentration. It is necessary to consider not only consolidation treatments of the plaster or the paint layer, which as such may influence the transition behaviour of the salts, but also the influence of microbial extracellular slimes on the porosity of the system. 

McCulley, R. (1998). Soil respiration and microbial biomass in a savanna parkland landscape spatio-temporal variation and environmental controls. M.S. thesis, Texas A M University, College Station, Texas. 

Details of environmental controls like temperature, humidity, microbial count in the sterile working area. 

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