Enterotoxigenic E. coli

Oyofo BA, el Etr SH, Wasfy MO, Peruski L, Kay B, Mansour M, Campbell JR, Svenner-holm AM, Churilla AM, Murphy JR Colonization factors of enterotoxigenic E. coli (ETEC) from residents of northern Egypt. Microbiol Res 1995 150 429-436. 

Enterotoxigenic E. coli B subunits of the heat labile toxin (LTB) Maize seed Elicited neutralizing antibodies. Immunogenic when administered orally. Serum and secretory immune responses in humans. Partially protective in mouse gut fluid assay. 27-29, 89, unpublished data... 

Enterotoxigenic E. coli epitope and rotavirus epitope fused to CTB Potato tuber Mice developed detectable levels of serum and intestinal antibodies. Immunogenic in mice against ETEC, rotavirus, and V. cholerae when delivered orally. Symptoms reduced in passively immunized mouse neonates following rotavirus challenge. 63... 

Escherichia coli GI disease may be caused by enterotoxigenic E. coli (ETEC), enteroinvasive E. coli, enteropathogenic E. coli, enteroadhesive E. coli, and enterohemorrhagic E. coli. ETEC is now incriminated as being the most common cause of traveler s diarrhea. 

Enterotoxigenic E. coli (ETEC) is the main cause of TD in Latin America, whereas in Asia it is reported in only 15% of cases. Enteroinvasive E. coli (EIEC) strains are recorded with even less frequency. ETEC is isolated in 0 to 5% of cases. Symptoms of poisoning develop after 16 hours from consumption of contaminated water, salads, cheeses, or meats. The outgrowth of ETEC rods takes place in a patient s gastrointestinal tract, where they produce thermostable and thermolabile toxins that imitate Vibrio cholerae infections. Stimulation of intestinal guanylcyclase and interruption of ion transport leads to watery stools, which do not require medical treatment or only need simple replacement of fluids and salts by means of multielectrolyte solutions. If a co-infection with EIEC strains occurs, the symptoms of enteritis will develop, with the presence of leukocytes, erythrocytes, and mucous in stools due to a cytotoxic influence of bacteria (Butterton and Claderwood, 2001). 

Travelers diarrhea in adults - Travelers diarrhea in adults caused by susceptible strains of enterotoxigenic E. coli. 

In addition to screening libraries of bacteria containing recombinant DNA, this method is also useful for genetic characterization of a variety of organisms. An example is the detection of enterotoxigenic E. coli (Moseley et al., 1980 Maas, 1983). 

Enterotoxigenic E. coli are capable of producing two plasmid-mediated enterotoxins heat-labile toxin (HLT) and heat-stable toxin (HST)." A cholera-like toxin, HLT has two subunits (A and B) that... 

EPEC = enteropathogenic f. coli ETEC = enterotoxigenic E. coli. 

Other reports also support a role for bacterial lectins in natural infections. Sialylated glycoproteins, administered orally, protected colostrum-deprived, newborn calves against lethal doses of enterotoxigenic E. coli K99[158]. In a clinical trial in humans, patients with otitis externa (a painful swelling with secretion from the external auditory canal) caused by P. aeruginosa were treated at the site of infection with a solution of galactose, mannose and AT-acetylneuraminic acid. The results were fully comparable to those obtained with conventional antibiotic treatment [159]. 

Buts L, Bouckaert J, De Genst E et al. (2003) The fimbrial adhesin F17-G of enterotoxigenic E. coli has an immunoglobulin like lectin domain that binds A-acetylgl ucosam i ne. Mol... 

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