6-Endotoxin injected toxicity

Table I. Injected toxicity of aikaline-solubilized BTI (Sandoz, Track 2) and BTK (Salsbury, Track 1) 6-endotoxin.

Quil-A saponin toxicity. Mice fed Quil-A-supplemented diet (a saponin that emulsifies fats and potentiates the immune responses) showed higher level of docosa-pentaenoic acid in the liver. These changes were associated with a significant reduction in the plasma PGEl and PGE2 and thrombohane-B2 levels in response to an intraperitoneal injection of a lethal dose of lipopolysaccharide endotoxin, LDjf, 20 mg/ kg. The data suggest that sesame seed oil and Quil A, when present in the diet, exerted cumulative effects that resulted in a decrease in the levels of dienoic eicosanoids with a reduction in lL-1 P and a con-commitant elevation in the levels of lL-10 that were associated with a marked increase survival in mice . ... 

The alkaline-dissolved 6-endotoxin of BTI (Sandoz, Track 2) was toxic by injection to all animals tested except Tenebrio molitor (Coleoptera Tenebrionidae) (Table I). Mice,... 

The basis for this difference is unknown but these species differences could be useful in the elucidation of the mechanism for toxicity. BTI toxicity by injection also was not peculiar to the Sandoz strain but was also noted for the IFC-1 strain from Salsbury (Table III). By contrast the alkaline-dissolved 6-endotoxin of BTK (Track 1) showed no toxicity when injected into the same species (Table I). Obvious fundamental differences exist between the dissolved 6-endotoxin of BTI and BTK. 

Table III. Toxicity of partially purified alkaline-solubilized BTI 6-endotoxin fed and injected into A. aegypti and T. n, respectively.

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