Encoding transcripts

Immediate early genes, e.g., c-fos, c-jun, and c-myc, are the first genes whose expression is induced in cells after a growth stimulus. They encode transcription factors and induce the expression of other growth-related genes. 

Zappavigna, V., Renucci, A., Izpisua-Belmonte, J. C., Urier, G Peschle, C., and Duboule, D. (1991). HOX 4 genes encode transcription factors with potential auto- and cross-regulatory capacities. EMBO J. 10 4177-4187. 

Genetic Modification of Flavonoid Production in Stably Transformed Plants or Cell Lines by Introduction of Genes Encoding Transcription Factors that Regulate Flavonoid Biosynthetic Genes (All "Sense Transgenes)... 

Oncogenic activation of transcription factors due to chromosome translocation is often observed in leukemias. Tlie aberrant activation by translocation of genes encoding transcription factors occurs mainly by two mechanisms (Look, 1997) ... 

In eukaryotes, individual genes encode transcripts for a single polypeptide chain. Although functionally re-... 

Finally, the expression of viral genes is a hallmark of certain tumors, such as Burkitt s lymphoma. To direct gene expression selectively to Burkitt s lymphoma cells, regulatory elements responsive to the Epstein-Barr virus-(EBV-) encoded transcriptional activators, EBNA-1 or EBNA-2, have been used to construct promoters with an extremely high degree of specificity [76-78], Obviously, this kind of approach might be applicable to a variety of human tumors that have been associated with specific oncogenic viruses. 

CREB, the CRE-binding protein is encoded by the crb s, a family of genes, encoding transcription factors. The CREB s are activated by phosphorylation by cAMP-dependent kinase and bind as dimers to CRE. 

Homeobox is a short, 180 base pair long DNA sequence present in homeotic genes. The homeobox encodes transcriptional regulators with characteristic DNA-binding motife. 

MYC is a family of genes that encode transcription factors. The cellular protooncogene c-myc is one of seven related genes. 

REL is a family of genes, encoding transcription factors of the kH family, v-rel is the oncogene of an avian reticuloendothelial virus. Rel encodes proteins which form homo-and heterodimers that bind to genes, which are also adressed by NF-icB. 

Jia, X., Reisman, J. M., Hsu, V. L., Geiduschek, E. P., Parello, J. Kearns, D. R. (1994). Proton and nitrogen NMR sequence-specific assignments and secondary structure determination of the Bacillus subtilis SPOl-encoded transcription factor 1. Biochemistry 33, 8842-8852. 

Kadonaga, J. T., Carrier, K. R., Fasiar F- R and Tjian, R. (1987). Isolation of cDNA encoding transcription factor Spl and functional analysis of the DNA binding domain. Cell 51, 1079-1090. 

---