Emodin, antimicrobial activity

To demonstrate this application, we used the BacTiter-Glo Assay to screen some LOP AC compounds (Rack 8, enzyme inhibitors, total of 80 compounds) for antimicrobial activity against S. aureus. The results were shown in Fig. 2. All positive controls of standard antibiotics (boxed points) and three LOPAC compounds (circled points) exhibited significant anti-S. aureus activity. The three LOPAC hits were D6 emodin Dll sanguinarine chloride and H7 minocycline. Their anti-5, aureus activities were reported in the literature previously. ... 

Anthraquinones and xanthones are also important constituents of many lichens. Anthraquinmies such as parietin, parietinic acid, emodin, fallacinol, and fallacinal were shown to have a high antimicrobial effect (Manojlovic et al. 2002). Manojlovic et al. (2010) found that the antimicrobial activity of Uchen Laurera benguelensis is mainly related to the presence of Uchexanthone. 

Kyung KH, Lee YC (2001) Antimicrobial activities of sulfur compounds derived from S-alk (en) yl-L-cysteine sulfoxides in Allium and Brassica. Food Rev Int 17 183-198 Lee YS, Kang OH, Choi JG, Oh YC, Keum JH, Kim SB, Jeong GS, Kim YC, Shin DW, Kwon DY (2010) Synergistic effect of emodin in combination with ampicillin or oxacillin against methicUlin-resistant Staphylococcus aureus. Pharm Biol 48 1285-1290 Li Y, Du Y, Zou C (2009) Effects of pH on antioxidant and antimicrobial properties of tea saponins. Eur Food Res Technol 228 1023-1028... 

Streptococcus pyogenes (90). The activity of three compounds (aloe-emodin, chiysophanol and aloin A) isolated from A. ferox have been shown to be effective against both Gram negative and Gram positive bacteria, demonstrating a broad spectram potential of the plant as antimicrobial agent (97). 

---