Electrospun polyester scaffolds functionalization

Physical and chemical modifications to increase electrospun polyester hydrophihcity and surface scaffold functionalization with ECM proteins, peptides, or other bioactive molecules are some examples of posttreatments in use [16]. Another strategy to improve the biocompatibihty of the scaffolds is to combine the polyester with a natural polymer or other natural biomolecule to conduct the electrospinning process [17,18]. 

Inspired by the hierarchical structures that enable bone function, Deng et al. recently developed a mechanically competent 3D scaffold mimicking the bone marrow cavity and the lamellar structure of bone by orienting electrospun polyphosphazene-polyester blend nanofibers in a concentric manner with an open central cavity (Figure 11.9b and c) [66]. The 3D biomimetic scaffold exhibited mechanical characteristic similar to native bone. Compressive modulus of the scaffold was found to be within the range of human trabecular bone. When tuned to have desired properties, the concentric open macrostructures of nanofibers that structurally and mechanically mimic the native bone can be a potential scaffold design for accelerated bone healing. 

Functionalization of Polyester Electrospun Scaffolds with Bioactive Molecules... 

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