Electrochemical recognition method

Effective charge and transition-state structure in solution, 27, 1 Effective molarities of intramolecular reactions, 17,183 Electrical conduction in organic solids, 16,159 Electrochemical methods, study of reactive intermediates by, 19, 131 Electrochemical recognition of charged and neutral guest species by redox-active receptor molecules, 31, 1... 

Despite being relatively new technology, aptamers have a tremendous potential and can be envisioned to rival antibodies and other traditional recognition elements for molecular detection and recognition, due to their inherent affinity, selectivity, and ease of synthesis. In addition, the combination of aptasensors with electrochemical detection methods has the added advantage of further cost reduction and miniaturization of such systems. 

Instead, a wide variety of spectroscopic and electrochemical titration methods are often employed to determine the equilibrium constants for a molecular recognition process at several different temperatures, which are then analyzed by the van t Hoff equation to give the thermodynamic parameters for the process. However, there is a critical tradeoff between the accuracy of the value obtained and the convenience of the measurement since the thermodynamic parameters, evaluated through the van t Hoff treatment, do not take into account the possible temperature dependence of the enthalpy change, i.e. heat capacity, and are less accurate in principle. In fact, it has been demonstrated with some supramolecular systems that the van t Hoff treatment leads to a curved plot and therefore the thermodynamic parameters deviated considerably from those determined by calorimetry.3132 Hence one should be cautious in handling thermodynamic parameters determined by spectroscopic titration and particularly in comparing the values for distinct systems determined by different methods. 

Rezaei-Zarchi S, Saboury AA, Norouzi P et al (2007) Electrochemical recognition of metalloproteins by bromide-modified silver electrode - a new method. Int J Mol Sci 8 ... 

Shervedani, R.K. and Bagherzadeh, M. (2009) Electrochemical impedance spectroscopy as a transduction method for electrochemical recognition of zirconium on gold electrode modified with hydroxamated self-assembled monolayer. Sens. Actuators B, 139, 657-664. 

A review of biochips and microarrays [4] considers requirements for biochemical and medical diagnostic applications, focusing on sihcon manufacturing technology coupled with magnetic beads, nucleic acid recognition, and enzyme catalysis. This review includes optical as well as electrochemical measurement methods. 

The potential of ECL in analytical chemistry has only more recently been investigated, but has rapidly gained recognition as both a sensitive and selective method of detection. Most reported applications have utilized the tris(2,2 -bipyri-dyl) ruthenium(II) [Ru(bpy)32+] ECL reaction, or else the electrochemical initiation of more conventional CL reactions, but many other potentially useful systems have been investigated. The applications of ECL in analytical chemistry have recently been the subject of comprehensive reviews [12-16],... 

Interface, the air-water, chirality and molecular recognition in monolayers at, 28, 45 Intermediates, reactive, study of, by electrochemical methods, 19, 131 Intermediates, tetrahedral, derived from carboxylic acids, spectroscopic detection and investigation of their properties, 21, 37 Intramolecular reactions, effective molarities for, 17, 183 Intramolecular reactions, of chain molecules, 22, 1... 

Interface, the air-water, chirality and molecular recognition in monolayers at, 28, 45 Intermediates, reactive, study of, by electrochemical methods, 19, 131... 

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