Guest neutral

Host-guest complexes in foldamer structures are based on the combination of different non-convalent interactions, which force the polymer to fold into a helical structure around the guest. In the past years, many oligomers have been synthesized with the aim to complex with guests. Neutral (polar. 

Vogtle, F., Muller, W. M., and Watson, W. H. Stereochemistry of the Complexes of Neutral Guests with Neutral Crown Host Molecules, 125, 131-164 (1984). 

Transition Metal and Organic Redox-Active Macrocycles Designed to Electrochemically Recognize Charged and Neutral Guest Species Paul D. Beer... 

Pharmacoeconomic studies of other dmgs are fewer and, as with clozapine, rely on less robusr merhods. Risperidone is probably associared wirh lower costs. A Swedish study applying UK costs to patient outcomes showed a reduction in mean direct costs of about 7500 per patient per year (Guest et al, 1996). Other studies, however, show risperidone ro be cost-neutral (Revicki, 1999). There are fewer studies of olanzapine (although there are many publications), and taken together they suggest the dmg is at least cost-neutral with respect to immediate costs (Fichner et al, 1998 Hamilton et al, 1999). 

A cage-like complex results from the tris(imidazol-l-ylmethyl)benzene ligand in the presence of zinc acetate, [Zn3L2(OAc)6], and exhibits inclusion properties to neutral guest molecules in aqueous solution.134... 

Zimmermann, S.C. Rigid Molecular Tweezers as Hosts for the Complexation of Neutral Guests. 165, 71-102 (1993). 

Effective charge and transition-state structure in solution, 27, 1 Effective molarities of intramolecular reactions, 17,183 Electrical conduction in organic solids, 16,159 Electrochemical methods, study of reactive intermediates by, 19, 131 Electrochemical recognition of charged and neutral guest species by redox-active receptor molecules, 31, 1... 

Receptor molecules, redox-active, electrochemical recognition of charged and neutral guest species... 

The macrotricyclic ligands (240) and (241) may be synthesized by multistep high-dilution procedures (Graf Lehn, 1975). They contain spherical cavities which are able to accommodate suitable guests whether they be cationic, neutral, or anionic. 

X-ray diffraction analysis show that these receptors can bind neutral and anionic bidentate guests species, e.g. 1,4-diazabicyclo[2.2.2]octane, isonicotin-ate, or terephthalate to form 1 1 intramolecular inclusion complexes.415... 

Since the seminal work of Cram on cyclophanes and resorci-narenes (1) the host-guest chemistry of container molecules has been extensively investigated and more sophisticated examples with other forms and larger cavities have been reported. Thus a large number of host-guest complexes containing neutral,... 

Molecular Recognition of Neutral and Charged Guests using Metallomacrocyclic Hosts Ivan V. Korendovych, Rebecca A. Roesner and Elena V. Rybak-Akimova... 

Concerted mechanism, of neutral phosphate esters, 305-308 general mechanism, 306 Cyanine dyes, for binding dynamics study of guests to DNA, 203, 204... 

There are several cases that have addressed molecular recognition of chiral drugs by modified CDs127 as well as inclusion complexes of cationic, anionic and neutral organic compounds128 in order to understand the role of hydrophobic and electrostatic interactions between the functional groups on host and guest. 

Vogtle has developed this approach further and employed a series of anionic templates to prepare rotaxanes (instead of the neutral template in the above reaction) [65-67]. In this approach a phenolate, thiophenolate or sulfonamide anion is non-covalently bound to the tetralactam macrocycle (46) forming a host-guest complex via hydrogen bonding (see Scheme 21). 

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